Synthesis of Glycosides by Glycosynthases
Abstract
:1. Introduction
2. Glycoside Syntheses Using Glycosynthase Methods
2.1. Glucosynthases
2.2. Galactosynthases
2.3. Xylosynthases
2.4. Mannosynthases
2.5. Fucosynthases
2.6. Glycosynthase Variants of endo-β-N-Acetylglucosaminidases
3. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Donor | Acceptor | Product Yield (%) |
---|---|---|
1 | 4 | 9 80% |
5 | 10 49% | |
2 | 6 | 11 a 14% |
7 | 12 32% | |
3 | 8 | 13 91% |
Acceptor | Product | Yield (Selectivity) | |
---|---|---|---|
37 | 60 | 26% a (>95%, α-1,3) | |
6 | 61 | 62 | 55% (60:40 α-1,3/α-1,2) |
58 | 63 | 44% a (92%, α-1,3) | |
59 | 56 | 57 | 41% a (3:2 α-1,5/α-1,1) |
Type | Donor | Acceptor | Product (Yield, Selectivity) | References |
---|---|---|---|---|
Chemical | 74 2 Steps 83% | 75 2 Steps 50% a | 76 Glycosylation 61% Deprotection of 76 81% (2 Steps 49%) | [84,85,86] |
Enzymatic | 15 2 Steps 21% b | 6 commercially available | 61 62 55% (60:40 α-1,3/α-1,2) | [55,87] |
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Hayes, M.R.; Pietruszka, J. Synthesis of Glycosides by Glycosynthases. Molecules 2017, 22, 1434. https://doi.org/10.3390/molecules22091434
Hayes MR, Pietruszka J. Synthesis of Glycosides by Glycosynthases. Molecules. 2017; 22(9):1434. https://doi.org/10.3390/molecules22091434
Chicago/Turabian StyleHayes, Marc R., and Jörg Pietruszka. 2017. "Synthesis of Glycosides by Glycosynthases" Molecules 22, no. 9: 1434. https://doi.org/10.3390/molecules22091434