Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus
Abstract
:1. Introduction
2. Results and Discussion
2.1. Nematicidal Activities of 3-Acyltetramic Acids
2.2. Structure-Activity Relationship
2.3. Physiocochemical Property–Nematicidal Activity Relationships
3. Materials and Methods
3.1. Chemicals
3.2. Collection of the Pine Wood Nematode
3.3. Nematicidal Activity Test
3.4. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
Compounds 1 | Mortality (%, Mean ± SE, n = 4) | ||
---|---|---|---|
10 2 | 5 | 2.5 | |
1c | 99.6 ± 0.7a 3 | 96.2 ± 0.9a | 15.0 ± 3.0bc |
1d | 85.8 ± 3.5a | 80.2 ± 6.8ab | 35.5 ± 3.2a |
1h | 88.0 ± 7.3a | 0.7 ± 1.3e | − 4 |
2c | 100a | 66.8 ± 8.1bc | 6.3 ± 0.5cd |
2f | 95.8 ± 1.1a | 76.4 ± 3.1b | 10.8 ± 2.8c |
2g | 98.9 ± 1.9a | 96.4 ± 1.8a | 6.3 ± 3.6cd |
2k | 57.2 ± 18.8b | 50.6 ± 10.1c | 13.1 ± 3.9c |
Emamectin benzoate | 32.3 ± 2.7c | 28.2 ± 3.9d | 24.1 ± 4.3b |
Control | 0d | 0e | 0d |
F8, 27 = 80.208 p < 0.0001 | F8, 27 = 156.542 p < 0.0001 | F7, 24 = 41.067 p < 0.0001 |
Compounds | Mw 1 | MSA(A 3) 2 | PSA(A 2) 3 | rel-PSA (%) 4 | ClogP 5 | ClogD7.4 6 | H-D 7/H-A 8 | RB 9 |
---|---|---|---|---|---|---|---|---|
1c | 366 | 674 | 57.6 | 8.55 | 5.12 | 4.51 | 1/3 | 15 |
1d | 394 | 735 | 57.6 | 7.84 | 5.92 | 5.30 | 1/3 | 17 |
1h | 410 | 721 | 83.9 | 11.6 | 5.13 | 4.26 | 1/4 | 14 |
2c | 380 | 673 | 74.7 | 11.1 | 4.69 | 3.91 | 1/4 | 14 |
2f | 366 | 674 | 57.6 | 8.55 | 5.12 | 4.51 | 1/3 | 15 |
2g | 394 | 735 | 57.6 | 7.84 | 5.92 | 5.30 | 1/3 | 17 |
2k | 378 | 642 | 74.7 | 11.6 | 4.77 | 3.92 | 1/4 | 13 |
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Lee, H.-R.; Lee, S.-C.; Lee, J.-E.; Seo, S.-M.; Jeong, Y.-C.; Jung, C.-S.; Moloney, M.G.; Park, I.-K. Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus. Molecules 2017, 22, 1568. https://doi.org/10.3390/molecules22091568
Lee H-R, Lee S-C, Lee J-E, Seo S-M, Jeong Y-C, Jung C-S, Moloney MG, Park I-K. Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus. Molecules. 2017; 22(9):1568. https://doi.org/10.3390/molecules22091568
Chicago/Turabian StyleLee, Hyo-Rim, Sung-Chan Lee, Ji-Eun Lee, Seon-Mi Seo, Yong-Chul Jeong, Chan-Sik Jung, Mark G. Moloney, and Il-Kwon Park. 2017. "Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus" Molecules 22, no. 9: 1568. https://doi.org/10.3390/molecules22091568