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Molecules
Volume 23
Issue 8
10.3390/molecules23081914
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Review

Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation

by
Xuelei Lai
†,
Leonie Verhage
†,
Veronique Hugouvieux
and
Chloe Zubieta
*
Laboratoire de Physiologie Cellulaire et Végétale, CNRS, Univ. Grenoble Alpes, CEA, INRA, BIG, 38000 Grenoble, France
*
Author to whom correspondence should be addressed.
†
These two authors contributed equally to this work.
Molecules 2018, 23(8), 1914; https://doi.org/10.3390/molecules23081914
Submission received: 9 July 2018 / Revised: 26 July 2018 / Accepted: 28 July 2018 / Published: 31 July 2018
(This article belongs to the Special Issue Protein-DNA Interactions: From Biophysics to Genomics)
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Abstract

Unlike most transcription factors (TF), pioneer TFs have a specialized role in binding closed regions of chromatin and initiating the subsequent opening of these regions. Thus, pioneer TFs are key factors in gene regulation with critical roles in developmental transitions, including organ biogenesis, tissue development, and cellular differentiation. These developmental events involve some major reprogramming of gene expression patterns, specifically the opening and closing of distinct chromatin regions. Here, we discuss how pioneer TFs are identified using biochemical and genome-wide techniques. What is known about pioneer TFs from animals and plants is reviewed, with a focus on the strategies used by pioneer factors in different organisms. Finally, the different molecular mechanisms pioneer factors used are discussed, highlighting the roles that tertiary and quaternary structures play in nucleosome-compatible DNA-binding.
Keywords: transcription factor; pioneer activity; cell fate transition; chromatin accessibility transcription factor; pioneer activity; cell fate transition; chromatin accessibility
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MDPI and ACS Style

Lai, X.; Verhage, L.; Hugouvieux, V.; Zubieta, C. Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation. Molecules 2018, 23, 1914. https://doi.org/10.3390/molecules23081914

AMA Style

Lai X, Verhage L, Hugouvieux V, Zubieta C. Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation. Molecules. 2018; 23(8):1914. https://doi.org/10.3390/molecules23081914

Chicago/Turabian Style

Lai, Xuelei, Leonie Verhage, Veronique Hugouvieux, and Chloe Zubieta. 2018. "Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation" Molecules 23, no. 8: 1914. https://doi.org/10.3390/molecules23081914

APA Style

Lai, X., Verhage, L., Hugouvieux, V., & Zubieta, C. (2018). Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation. Molecules, 23(8), 1914. https://doi.org/10.3390/molecules23081914

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