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Article

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction

by
Wei Lin
1,*,
Cangwei Zhuang
1,
Xiuxiu Hu
1,
Juanjuan Zhang
2 and
Juxian Wang
3,*
1
School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China
2
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
3
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(15), 2835; https://doi.org/10.3390/molecules24152835
Submission received: 10 July 2019 / Revised: 1 August 2019 / Accepted: 2 August 2019 / Published: 4 August 2019
(This article belongs to the Special Issue Modern Strategies for Heterocycle Synthesis)
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Abstract

A concise and efficient approach to synthesizing coumarin-fused pyrazolo[3,4-b]pyridine via silica sulfuric acid (SSA) catalyzed three-component domino reaction under microwave irradiation has been demonstrated. Participation of various alcohols in construction of coumarin derivatives has been described for the first time. Short reaction time, high yields, one-pot procedure, usage of eco-friendly catalyst, and solvent are the key features of this method.
Keywords: coumarin; pyrazolo[3,4-b]pyridine; synthesis; silica sulfuric acid coumarin; pyrazolo[3,4-b]pyridine; synthesis; silica sulfuric acid

Share and Cite

MDPI and ACS Style

Lin, W.; Zhuang, C.; Hu, X.; Zhang, J.; Wang, J. Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction. Molecules 2019, 24, 2835. https://doi.org/10.3390/molecules24152835

AMA Style

Lin W, Zhuang C, Hu X, Zhang J, Wang J. Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction. Molecules. 2019; 24(15):2835. https://doi.org/10.3390/molecules24152835

Chicago/Turabian Style

Lin, Wei, Cangwei Zhuang, Xiuxiu Hu, Juanjuan Zhang, and Juxian Wang. 2019. "Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction" Molecules 24, no. 15: 2835. https://doi.org/10.3390/molecules24152835

APA Style

Lin, W., Zhuang, C., Hu, X., Zhang, J., & Wang, J. (2019). Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction. Molecules, 24(15), 2835. https://doi.org/10.3390/molecules24152835

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