Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome
Abstract
:1. Introduction
2. Hematological Effects of Prostaglandin E2 (PGE2)
3. Concise Overview of Acute Radiation Syndrome
4. Prostaglandins Act Radioprotectively
5. Cyclooxygenases Carry out Prostaglandin Synthesis, Their Inhibition Can Be Selective
6. Effects of Non-Selective COX Inhibitors in Sublethally and Lethally Irradiated Experimental Animals
7. Effects of Selective COX-2 Inhibitors in Sublethally and Lethally Irradiated Experimental Animals
8. Summarization and Considerations on Hematological and Radiation-Modulating Effects of Selective COX-2 Inhibitor Meloxicam
9. Considerations Concerning Connecting Pharmacological Interventions with Prostaglandins and Inhibitors of Their Synthesis into One Treatment Scheme
10. Supplementary Note on COX-2-Deficient Mice, Hematopoiesis, and Myelosuppression
11. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Species | Mouse | Rat | Dog | Monkey (Macaca) | Rabbit | Guinea Pig | Hamster | Pig | Goat | Man |
---|---|---|---|---|---|---|---|---|---|---|
LD50/30 (Gy) | 6.4 | 7.1 | 2.5 | 6.0 | 7.5 | 4.5 | 6.1 | 2.5 | 2.4 | 3.0 * |
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Hofer, M.; Hoferová, Z.; Falk, M. Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome. Molecules 2019, 24, 4019. https://doi.org/10.3390/molecules24224019
Hofer M, Hoferová Z, Falk M. Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome. Molecules. 2019; 24(22):4019. https://doi.org/10.3390/molecules24224019
Chicago/Turabian StyleHofer, Michal, Zuzana Hoferová, and Martin Falk. 2019. "Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome" Molecules 24, no. 22: 4019. https://doi.org/10.3390/molecules24224019