Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques
Abstract
:1. Introduction
2. Antibiotics
2.1. Nitroimidazoles
2.2. Fluoroquinolones
2.3. Tetracyclines
2.4. Sulfonamides
2.5. Aminoglycosides
2.6. Macrolides
2.7. β-Lactam Antibiotics
2.8. Simultaneous Analysis of Different Antibiotics
3. Other Drugs
3.1. Estrogens
3.2. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
3.3. β-Agonists
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References and Notes
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CE-Technique | Food Matrix | Sensitivity | Ref. |
---|---|---|---|
Nitroimidazoles | |||
LLE-SPE-CEC-UV | bovine milk | LOQ: 19–96 (μg/L) | [38] |
DLLME-CEC-UV | water | LOQ: 5.7–9.3 (μg/L) | [41] |
DLLME-CZE-MS/MS | poultry and porcine meat | LOQ: 4–16 (μg/kg) | [44] |
DLLME-CSEI-sweep-MEKC-UV | water | LOQ: 2.05–8.14 (ng/mL) | [43] |
SPE-CSEI-sweep-MEKC-UV | egg | LOQ: 6.99–16.8 (ng/g) | [45] |
Fluoroquinolones | |||
SPE-CZE-UV | bovine milk | LOD: 7.5–11.6 (μg/L) | [28] |
MMMIPs-CZE-UV | bovine milk | LOD: 12.9–18.8 (μg/L) | [29] |
PPT/SPE-CZE-UV | bovine milk | LOQ: 0.06–0.1 (mg/kg) | [50] |
MISPE-CZE-LIF | bovine milk, pig kidney | LOQ: 0.55–35 (μg/kg) | [52] |
MISPE-CZE-MS/MS | bovine milk | LOQ: 3.2–4.7 (μg/kg) | [53] |
PLE-SPE-CZE-MS/MS | meat | LOQ: 130–470 (ng/kg) | [54] |
FASS-sweep-CZE-UV | milk, meat | LOD: 5.70, 7.39 (ng/mL) | [55] |
FESI-CZE-UV and CZE-MS | bovine milk | LOQ: 2.3–8.3 (μg/kg) | [56] |
DLLME-NACE-UV | water | LOQ: 5.43–461 (μg/L) | [57] |
SD-LLLME-NACE-UV | water | LOD: 10.1, 55.3 (μg/L) | [58] |
Tetracyclines | |||
CZE-ECL | fish | LOD: 1.8 ng/mL | [60] |
FASI-CZE-UV | water | LOQ: 23–59 μg/L | [61] |
SPE-LVSS-PS-CZE-UV | milk | LOD: 18.60–23.83 (μg/L) | [62] |
MSPD-CZE-UV | milk | LOD: 0.0745–0.0808 (μg/mL) | [65] |
SPE-LVSS-PS-CZE-UV | water | LOQ: 67–167 (ng/L) | [63] |
LVSS-CZE-UV | water | LOD: 8.1–14.5 (μg/L) | [64] |
CZE-AD | water | LOD: 0.33–0.67 (μM) | [66] |
SPE- CZE-UV | honey | LOD: 23.9–49.3 (μg/kg) | [67] |
Sulfonamides | |||
SPE-CEC-MS | meat | LOD: 0.01–0.14 (μg/L) | [71] |
microchip-CE-LIF | milk, meat | LOQ: 0.6–7.7 (μg/L) | [72] |
SPE-CZE-ECL | milk, meat | LOD: 0.62–3.14 (μg/mL) | [73] |
CZE-UV and CZE-MS | meat, water | LOD: 0.33–180 (μg/L) | [68] |
CITP-CZE-UV | beverages, water | LOD: 2.29 (ng/mL) | [69] |
Aminoglycosides | |||
MISPE-FASS-CZE-MS/MS | honey | LOQ: 1.4–94.8 (μg/kg) | [75] |
microchip-CE-CCD | standard solutions | LODs: 0.89–3.1 (μg/mL) | [77] |
Macrolides | |||
FASS-MEKC-UV | milk | LOD: 0.002–0.004 (mg/kg) | [83] |
R-USAEME-CZE-DAD | chicken fat | LOQ: 22.1–47.0 (μg/kg) | [84] |
β-lactam antibiotics (penicillins) | |||
PPT/CZE-UV | milk | LOQ: 0.04–1.7 (μg/mL) | [89] |
ASEI-CEC-MS | milk | LOD: 0.05–0.2 (μg/L) | [90] |
β-lactam antibiotics (cephalosporins) | |||
CZE-UV | complex matrices | LOQ: 4.33–8.00 (μg/mL) | [88] |
Estrogens | |||
SPE-p-CEC-AD | bovine milk, diary products | LOD: 2–50 (ng/mL) | [98] |
DLLME-MEKC-ESI-MS/MS | bovine and goat milk, diary products | LOD: 1–61 (μg/L) | [32] |
DLLME-MEKC-UV | water | LOD: 0.3–0.6 (μg/L) | [33] |
NSAIDs | |||
DLLME-FASS-CZE-UV | bovine milk, dairy products | LOQ: 10–43.7 (μg/kg) | [99] |
SPME-CZE-UV | water | LOQ: 2.91–3.86 (μg/L) | [102] |
β-agonists | |||
SPE-NACE-MS | meat | LOD: 0.3 (ppb) | [103] |
CSEI-sweep-MEKC-UV | meat | LOD: 3–5 (ng/g) | [104] |
FASI-sweep-MEKC-UV | commercial animal feeds | LOD: 5–20 (ng/mL) | [105] |
FESI-CE-C4D | pig feed | LOD: 0.02 (mg/L) | [106] |
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Colombo, R.; Papetti, A. Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques. Molecules 2019, 24, 4617. https://doi.org/10.3390/molecules24244617
Colombo R, Papetti A. Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques. Molecules. 2019; 24(24):4617. https://doi.org/10.3390/molecules24244617
Chicago/Turabian StyleColombo, Raffaella, and Adele Papetti. 2019. "Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques" Molecules 24, no. 24: 4617. https://doi.org/10.3390/molecules24244617