Next Article in Journal
Extra Virgin Olive Oil Phenols Dilate the Rat Mesenteric Artery by Activation of BKCa2+ Channels in Smooth Muscle Cells
Next Article in Special Issue
Potential of Flavonoid-Inspired Phytomedicines against COVID-19
Previous Article in Journal
Encapsulated Limonene: A Pleasant Lemon-Like Aroma with Promising Application in the Agri-Food Industry. A Review
Previous Article in Special Issue
The Targeted Impact of Flavones on Obesity-Induced Inflammation and the Potential Synergistic Role in Cancer and the Gut Microbiota
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 25
Issue 11
10.3390/molecules25112599
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling

by
Yu-Chan Ko
1,†,
Hack Sun Choi
2,†,
Ren Liu
1,
Ji-Hyang Kim
1,
Su-Lim Kim
1,
Bong-Sik Yun
3 and
Dong-Sun Lee
1,2,3,4,5,*
1
Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea
2
Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, Korea
3
Division of Biotechnology, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan 54596, Korea
4
Practical Translational Research Center, Jeju National University, Jeju 63243, Korea
5
Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, SARI, Jeju 63243, Korea
*
Author to whom correspondence should be addressed.
†
Yu-Chan Ko and Hack Sun Choi contributed equally to this work.
Molecules 2020, 25(11), 2599; https://doi.org/10.3390/molecules25112599
Submission received: 20 May 2020 / Revised: 1 June 2020 / Accepted: 2 June 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Flavonoids and Their Disease Prevention and Treatment Potential)
Browse Figures
Review Reports Versions Notes

Abstract

Breast cancer stem cells (BCSCs) are responsible for tumor chemoresistance and recurrence. Targeting CSCs using natural compounds is a novel approach for cancer therapy. A CSC-inhibiting compound was purified from citrus extracts using silica gel, gel filtration and high-pressure liquid chromatography. The purified compound was identified as tangeretin by using nuclear magnetic resonance (NMR). Tangeretin inhibited cell proliferation, CSC formation and tumor growth, and modestly induced apoptosis in CSCs. The frequency of a subpopulation with a CSC phenotype (CD44+/CD24−) was reduced by tangeretin. Tangeretin reduced the total level and phosphorylated nuclear level of signal transducer and activator of transcription 3 (Stat3). Our results in this study show that tangeretin inhibits the Stat3 signaling pathway and induces CSC death, indicating that tangeretin may be a potential natural compound that targets breast cancer cells and CSCs.
Keywords: tangeretin; cancer stem cells; Stat3; citrus; CD44+/CD24−; phytochemicals tangeretin; cancer stem cells; Stat3; citrus; CD44+/CD24−; phytochemicals

Share and Cite

MDPI and ACS Style

Ko, Y.-C.; Choi, H.S.; Liu, R.; Kim, J.-H.; Kim, S.-L.; Yun, B.-S.; Lee, D.-S. Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling. Molecules 2020, 25, 2599. https://doi.org/10.3390/molecules25112599

AMA Style

Ko Y-C, Choi HS, Liu R, Kim J-H, Kim S-L, Yun B-S, Lee D-S. Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling. Molecules. 2020; 25(11):2599. https://doi.org/10.3390/molecules25112599

Chicago/Turabian Style

Ko, Yu-Chan, Hack Sun Choi, Ren Liu, Ji-Hyang Kim, Su-Lim Kim, Bong-Sik Yun, and Dong-Sun Lee. 2020. "Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling" Molecules 25, no. 11: 2599. https://doi.org/10.3390/molecules25112599

APA Style

Ko, Y.-C., Choi, H. S., Liu, R., Kim, J.-H., Kim, S.-L., Yun, B.-S., & Lee, D.-S. (2020). Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling. Molecules, 25(11), 2599. https://doi.org/10.3390/molecules25112599

Article Metrics

Back to TopTop