Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Design and Chemistry
2.2. Antimicrobial Assay
3. Experimental
3.1. Chemistry
3.1.1. General Procedure for the Synthesis of Sulfonamide Ligand 3a and its Complexes 4a–d
Synthesis of the Ligand
Synthesis of the Complexes
3.2. Antimicrobial Assay
3.2.1. Disk-Diffusion Method
3.2.2. Broth Microdilution Method
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are available from the authors. |
ν (cm−1) | Sulfonamide Ligand (3a) | Zinc Complex (4a) | Copper Complex (4b) | Cobalt Complex (4c) | Cadmium Complex (4d) |
---|---|---|---|---|---|
νN-H | 3267 (m) | - | - | - | - |
νasSO2 | 1372 (s-m) | 1389 (s-m) | 1385 (s-m) | 1386 (s-m) | 1392 (s-m) |
νsymSO2 | 1177 (s) | 1138 (s) | 1155 (s) | 1151 (s) | 1136 (s) |
νC-N | 1584 (m) | 1583 (m) | 1583 (m) | 1584 (m) | 1578 (m) |
νS-N | 927 (m) | 954 (m) | 954 (m) | 961 (m) | 957 (m) |
νC-S | 624 (s) | 624 (s) | 629 (s) | 624 (s) | 621 (s) |
Strain | Diameter of | Inhibition Zone | |||
---|---|---|---|---|---|
a 3a | a 4a (Zn) | a 4b (Cu) | a 4c (Co) | a 4d (Cd) | |
S. aureus ATCC 25923 | 18 ± 1.73 | 11 ± 1.73 | 16 ± 1 | 17 ± 2 | 21± 2 |
E. coli ATCC 25922 | 0 | 12 ± 2 | 14.5 ± 2 | 10.7 ± 2 | 19 ± 1.73 |
C. albicans ATCC 10231 | 26.5± 1.80 | 12 ± 2 | 0 | 11 ± 1 | 25± 1.15 |
Strain | MIC (mg/mL) | ||||
---|---|---|---|---|---|
3a | 4a (Zn) | 4b (Cu) | 4c (Co) | 4d (Cd) | |
S. aureus ATCC 25923 | 12.5 | 25 | 0.04875 | 12.5 | 0.00019 |
E. coli ATCC 25922 | - | 25 | 0.04875 | 12.5 | 0.00609 |
C. albicans ATCC 10231 | 12.5 | 12.5 | - | 12.5 | 0.00019 |
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Diaconu, D.; Mangalagiu, V.; Amariucai-Mantu, D.; Antoci, V.; Giuroiu, C.L.; Mangalagiu, I.I. Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity. Molecules 2020, 25, 2946. https://doi.org/10.3390/molecules25122946
Diaconu D, Mangalagiu V, Amariucai-Mantu D, Antoci V, Giuroiu CL, Mangalagiu II. Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity. Molecules. 2020; 25(12):2946. https://doi.org/10.3390/molecules25122946
Chicago/Turabian StyleDiaconu, Dumitrela, Violeta Mangalagiu, Dorina Amariucai-Mantu, Vasilichia Antoci, Cristian Levente Giuroiu, and Ionel I. Mangalagiu. 2020. "Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity" Molecules 25, no. 12: 2946. https://doi.org/10.3390/molecules25122946