Next Article in Journal
A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy
Previous Article in Journal
Granzyme B PET Imaging of the Innate Immune Response
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 25
Issue 13
10.3390/molecules25133097
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.)

by
Barbara Chilczuk
1,
Beata Marciniak
2,
Anna Stochmal
3,
Łukasz Pecio
3,
Renata Kontek
2,
Izabella Jackowska
1 and
Małgorzata Materska
1,*
1
Department of Chemistry, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland
2
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
3
Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100 Puławy, Poland
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(13), 3097; https://doi.org/10.3390/molecules25133097
Submission received: 10 June 2020 / Revised: 2 July 2020 / Accepted: 2 July 2020 / Published: 7 July 2020
(This article belongs to the Section Natural Products Chemistry)
Browse Figures
Versions Notes

Abstract

This study aimed to determine the health-promoting properties of sweet pepper by comparing the activity of fractions with variable lipophilicity. Fractions from red pericarp: aqueous (F1), 40% MeOH (F2), and 70% MeOH (F3) were analyzed for antiradical activity (with DPPH• and ABTS+•), and the contents of total phenolic compounds (TP), flavonoids (TF), and dihydroxycinnamic acids (TDHCA). The anticancer potential of the fractions was evaluated in vitro using different cancer cell lines: human colorectal carcinoma (HCT116) and PC-3 (prostate cancer cell). Fibroblast-like cells of L929 obtained from subcutaneous adipose tissue of mouse were used as normal cells. The highest content of TP, TF, and TDHCA along with the strongest antiradical activity was observed for fraction F2, while the strongest anticancer properties against PC-3 were observed in fraction F3. Fraction F3 primarily contained capsianoside derivatives, which had been isolated through chromatographic methods and identified by spectral methods. These analyses helped in identifying 8 compounds, including 3 new compounds.
Keywords: Capsicum annuum; phenolic compounds; antiradical activity; anticancer properties; capsianoside; mass spectrometry; 1H- and 13C-NMR Capsicum annuum; phenolic compounds; antiradical activity; anticancer properties; capsianoside; mass spectrometry; 1H- and 13C-NMR
Graphical Abstract

Share and Cite

MDPI and ACS Style

Chilczuk, B.; Marciniak, B.; Stochmal, A.; Pecio, Ł.; Kontek, R.; Jackowska, I.; Materska, M. Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.). Molecules 2020, 25, 3097. https://doi.org/10.3390/molecules25133097

AMA Style

Chilczuk B, Marciniak B, Stochmal A, Pecio Ł, Kontek R, Jackowska I, Materska M. Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.). Molecules. 2020; 25(13):3097. https://doi.org/10.3390/molecules25133097

Chicago/Turabian Style

Chilczuk, Barbara, Beata Marciniak, Anna Stochmal, Łukasz Pecio, Renata Kontek, Izabella Jackowska, and Małgorzata Materska. 2020. "Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.)" Molecules 25, no. 13: 3097. https://doi.org/10.3390/molecules25133097

APA Style

Chilczuk, B., Marciniak, B., Stochmal, A., Pecio, Ł., Kontek, R., Jackowska, I., & Materska, M. (2020). Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.). Molecules, 25(13), 3097. https://doi.org/10.3390/molecules25133097

Article Metrics

Back to TopTop