Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats
Abstract
:1. Introduction
2. Results
2.1. Propofol Had Minimal Effect on Basal Glucose Level
2.2. Propofol Improved Impaired Glucose Tolerance
2.3. Propofol Increased the Circulating Level of Fibroblast Growth Factor-21 (FGF-21), Glucagon-like Peptide-1 (GLP-1), and Insulin
2.4. Propofol Upregulated FGF-21 Signaling in the Liver
3. Discussion
4. Materials and Methods
4.1. Animal Study
4.2. Blood Sample Reparation
4.3. Tissue Collection and Western Blot Analyses
4.4. RNA Preparation and Quantitative Real-Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)
4.5. Statistical Analysis
Author Contributions
Funding
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
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Wu, C.-C.; Hung, C.-J.; Wang, Y.-Y.; Lin, S.-Y.; Chen, W.-Y.; Kuan, Y.-H.; Liao, S.-L.; Yang, C.-P.; Chen, C.-J. Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats. Molecules 2020, 25, 3229. https://doi.org/10.3390/molecules25143229
Wu C-C, Hung C-J, Wang Y-Y, Lin S-Y, Chen W-Y, Kuan Y-H, Liao S-L, Yang C-P, Chen C-J. Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats. Molecules. 2020; 25(14):3229. https://doi.org/10.3390/molecules25143229
Chicago/Turabian StyleWu, Chih-Cheng, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Ching-Ping Yang, and Chun-Jung Chen. 2020. "Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats" Molecules 25, no. 14: 3229. https://doi.org/10.3390/molecules25143229