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Volume 25
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Review

Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

by
Bartłomiej Kost
*,
Marek Brzeziński
*,
Marta Socka
,
Małgorzata Baśko
and
Tadeusz Biela
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(15), 3404; https://doi.org/10.3390/molecules25153404
Submission received: 30 June 2020 / Revised: 23 July 2020 / Accepted: 24 July 2020 / Published: 28 July 2020
(This article belongs to the Special Issue Polylactide-Based Materials: Synthesis and Biomedical Applications)
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Abstract

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.
Keywords: polylactide; cyclodextrin; drug delivery systems; controlled release polylactide; cyclodextrin; drug delivery systems; controlled release

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MDPI and ACS Style

Kost, B.; Brzeziński, M.; Socka, M.; Baśko, M.; Biela, T. Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications. Molecules 2020, 25, 3404. https://doi.org/10.3390/molecules25153404

AMA Style

Kost B, Brzeziński M, Socka M, Baśko M, Biela T. Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications. Molecules. 2020; 25(15):3404. https://doi.org/10.3390/molecules25153404

Chicago/Turabian Style

Kost, Bartłomiej, Marek Brzeziński, Marta Socka, Małgorzata Baśko, and Tadeusz Biela. 2020. "Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications" Molecules 25, no. 15: 3404. https://doi.org/10.3390/molecules25153404

APA Style

Kost, B., Brzeziński, M., Socka, M., Baśko, M., & Biela, T. (2020). Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications. Molecules, 25(15), 3404. https://doi.org/10.3390/molecules25153404

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