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Article

Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing

by
Juanmei Zhang
1,2,
Fenghua Xu
1,
Lingling Yao
1,
Leyu Wang
1,
Miao Wang
2,3,* and
Gang Wang
2,3,*
1
School of Pharmaceutical, Henan University, Kaifeng 475004, China
2
Institute of Microbial Engineering, Laboratory of Bioresource and Applied Microbiology, School of Life Sciences, Hennan Univeristy, Kaifeng 475004, China
3
Engineering Research Center for Applied Microbiology of Henan Province, Kaifeng 475004, China
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(20), 4727; https://doi.org/10.3390/molecules25204727
Submission received: 16 August 2020 / Revised: 9 October 2020 / Accepted: 10 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Discovering New Natural Compounds with Pharmacological or Biotechnological Applications)
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Abstract

Chinese herbs are a useful resource bank for natural drug development, and have attracted considerable attention to exploit quorum sensing inhibitors (QSIs). This study was designed to screen QSIs from raw Chinese herb materials. Of the 38 common herbs examined, the ethanol extract of Campsis grandiflora flower had the strongest QSI activity. The C. grandiflora flower ethanol extract (CFEE) was purified by HPD600, and the QSI activities were examined in further detail. CFEE inhibited violacein production of Chromobacterium violaceum 026 in a dose-dependent manner, and inhibit the swarming abilities of Escherichia coli K-12 and Pseudomonas aeruginosa PAO1. Furthermore, CFEE could inhibited biofilm formation and destroyed mature biofilms of E. coli K-12 and P. aeruginosa PAO1. The composition of CFEE was determined by UPLC-MS/MS to distinguish active QSI compounds, and 21 compounds were identified. In addition to gallic acid and caffeic acid, two organic acids, malic acid and succinic acid, were confirmed for the first time to have autoinducer type 1 QSI activities. Therefore, CFEE is a potential QSI that could be used as a novel antimicrobial agent and should be considered for medicinal development.
Keywords: quorum sensing; Campsis grandiflora; biofilm; swarming; malic acid; succinic acid quorum sensing; Campsis grandiflora; biofilm; swarming; malic acid; succinic acid

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MDPI and ACS Style

Zhang, J.; Xu, F.; Yao, L.; Wang, L.; Wang, M.; Wang, G. Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing. Molecules 2020, 25, 4727. https://doi.org/10.3390/molecules25204727

AMA Style

Zhang J, Xu F, Yao L, Wang L, Wang M, Wang G. Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing. Molecules. 2020; 25(20):4727. https://doi.org/10.3390/molecules25204727

Chicago/Turabian Style

Zhang, Juanmei, Fenghua Xu, Lingling Yao, Leyu Wang, Miao Wang, and Gang Wang. 2020. "Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing" Molecules 25, no. 20: 4727. https://doi.org/10.3390/molecules25204727

APA Style

Zhang, J., Xu, F., Yao, L., Wang, L., Wang, M., & Wang, G. (2020). Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing. Molecules, 25(20), 4727. https://doi.org/10.3390/molecules25204727

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