Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis
Abstract
:1. Introduction
2. Results
2.1. Droplet Generation of Typical Organic Solvents
2.2. Droplet Generation of Organic Solvents Incompatible with High Chemical Resistance Resins
2.3. Droplet Size and Generation Rate Variation
3. Materials and Methods
3.1. Chemicals and Sample Preparation
3.2. Device Design and Fabrication
3.3. Channel Surface Treatment
3.4. Microfluidic Experiment Setup
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Dispersed Phase | Continuous Phase | Example Flow Rate at Which Droplets Were Generated | |||
---|---|---|---|---|---|
Surfactant | Dispersed Phase (µL/min) | Continuous Phase (µL/min) | Mean Droplet Length (µm) | Droplet Generation Rate (Hz) | |
Toluene | DI water | 1 | 3 | 286.3 ± 12.2 | 13.8 |
Tween 20 (4 wt %) | |||||
Chloroform | DI water | 1 | 3 | 183.4 ± 2.7 | 9.55 |
PVA (3 wt %) | |||||
Methanol | Mineral oil | 0.3 | 3 | 83.9 ± 1.0 | 23.9 |
Surflon S-656 (1 wt %) | |||||
DMSO | Diethyl ether | 0.4 | 8 | 56.8 ± 1.5 | 14.7 |
Span 80 (2 wt %) | |||||
THF | Saturated saline | 0.5 | 5 | 102.1 ± 0.8 | 17.6 |
Tween 20 (4 wt %) |
Dispersed Phase | Continuous Phase | Example Flow Rate at Which Droplets Were Generated | |||
---|---|---|---|---|---|
Surfactant | Dispersed Phase (µL/min) | Continuous Phase (µL/min) | Mean Droplet Length (µm) | Droplet Generation Rate (Hz) | |
Dichloromethane | DI water | 1 | 10 | 109.4 ± 1.75 | 47.6 |
PVA (1 wt %) | |||||
Acetone | PFC-based solvents | 1 | 3 | 112.3 ± 2.26 | 27.3 |
None | |||||
Acetonitrile | Fluorinated oil | 1 | 3 | 103.8 ± 3.3 | 29.6 |
None |
Dispersed Phase (Droplets) | Continuous Phase (Carrier) | |||
---|---|---|---|---|
Liquid | Type (Dipole Moment) | Liquid | Type | Solubility in the Dispersed-Phase Solution |
Toluene | Nonpolar sol. (0.36 D) | DI water | Protic polar sol. | 0.045 g/100 mL (20 °C) |
Chloroform | Nonpolar sol. (1.04 D) | DI water | Protic polar sol. | 0.8 g/100 mL (20 °C) |
Methanol | Protic polar sol. (1.70 D) | Mineral oil | Nonpolar sol. | Immiscible (No date) |
DMSO | Aprotic polar sol. (3.96 D) | Diethyl ether | Nonpolar sol. | Immiscible (No date) |
THF | Aprotic polar sol. (1.75 D) | Saturated saline | Protic polar sol. | 5.49 g/100 mL (25 °C) |
Acetone | Aprotic polar sol. (2.88 D) | PFC-based solvent | Nonpolar sol. | Immiscible (No date) |
Acetonitrile | Aprotic polar sol. (3.92 D) | HFE-based oil | Nonpolar sol. | Immiscible (No date) |
Dichloromethane | Aprotic polar sol. (1.60 D) | DI water | Protic polar sol. | 1.3 g/100 mL (20 °C) |
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Hattori, S.; Tang, C.; Tanaka, D.; Yoon, D.H.; Nozaki, Y.; Fujita, H.; Akitsu, T.; Sekiguchi, T.; Shoji, S. Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis. Molecules 2020, 25, 5360. https://doi.org/10.3390/molecules25225360
Hattori S, Tang C, Tanaka D, Yoon DH, Nozaki Y, Fujita H, Akitsu T, Sekiguchi T, Shoji S. Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis. Molecules. 2020; 25(22):5360. https://doi.org/10.3390/molecules25225360
Chicago/Turabian StyleHattori, Shohei, Chenghe Tang, Daiki Tanaka, Dong Hyun Yoon, Yoshito Nozaki, Hiroyuki Fujita, Takashiro Akitsu, Tetsushi Sekiguchi, and Shuichi Shoji. 2020. "Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis" Molecules 25, no. 22: 5360. https://doi.org/10.3390/molecules25225360