Glycerol and Glycerol-Based Deep Eutectic Mixtures as Emerging Green Solvents for Polyphenol Extraction: The Evidence So Far
Abstract
:1. Introduction
2. Glycerol-Properties, Sources and Uses
3. Use of Glycerol in Solid-Liquid Extraction of Polyphenolic Phytochemicals
3.1. Plant Food By-Products
3.2. Medicinal and Aromatic Plants (MAPs)
4. Glycerol-Based Deep Eutectic Solvents (DES) in Polyphenol Extraction
4.1. Glycerol as Hydrogen Bond Donor
4.2. Glycerol vs. Other Hydrogen Bond Donors
5. Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Plant Material | Glycerol Proportion | Extraction Mode | Conditions | Yield in Total Polyphenols (mg GAE g−1) | Reference |
---|---|---|---|---|---|
Olive leaves | 9.3% (w/v) | Stirred-tank | T = 80 °C; t = 241 min; RL/S = 60 mL g−1 | 51.91 | [29] |
Apple peels | 70% (w/v) | Stirred-tank | T = 80 °C; t = 160 min; RL/S = 100 mL g−1 | 16.59 | [31] |
Onion solid wastes | 90% (w/v) | Ultrasound-assisted | T = 50 °C; t = 60 min; RL/S = 90 mL g−1 | 90.07 | [32] |
Red grape pomace | 90% (w/v) | Ultrasound-assisted | T = 45 °C; t = 60 min; RL/S = 90 mL g−1 | 66.70 | [33] |
Coffee brewing residues | 3.6% (w/v) | Ultrasound-assisted | T = 45 °C; t = 175 min; RL/S = 50 mL g−1 | 8.15 | [34] |
Eggplant peels, potato peels, coffee brewing residues | 80% (w/v) | Stirred-tank | T = 80 °C; t = 180 min; RL/S = 100 mL g−1 | [35] | |
Red grape pomace | 20% (w/v) | Stirred-tank | T = 23 °C; t = 180 min, RL/S = 50 mL g−1 | 5.65 | [36] |
Potato peels | 83% (w/v) | Ultrasound-assisted | T = 23 °C; t = 80 min, RL/S = 81 mL g−1 | 8.71 | [37] |
Eggplant peels | 90% (w/v) | Ultrasound-assisted | T = 50 °C; t = 90 min, RL/S = 100 mL g−1 | 13.51 | [38] |
Oak acorn husks | 60% (w/v) | Stirred-tank, addition of 13% (w/v) HP-β-CD 1 | T = 80 °C; t = 180 min, RL/S = 50 mL g−1 | 122.19 | [39] |
Olive leaves | 60% (w/v) | Stirred-tank, addition of 7% (w/v) HP-β-CD 1 | T = 60 °C; t = 180 min, RL/S = 50 mL g−1 | 54.33 | [40] |
Onion solid wastes | 60% (w/v) | Stirred-tank, addition of 13% (w/v) HP-β-CD 1 | T = 80 °C; t = 240 min, RL/S = 50 mL g−1 | 3.13 | [41] |
Rice bran | 19.5% (v/v) | Orbital shaking | T = 67 °C; t = 90 min, RL/S = 33 mL g−1 | 7.09 | [42] |
Rice bran | 15.9% (w/v) | Orbital shaking | T = 90 °C; RL/S = 31.6 mL g−1 | 5.50 | [43] |
Grapefruit peels | 20% (w/v) | Stirred-tank, HVED 3 pretreatment | T = 50 °C; t = 60 min | 19.3 | [44] |
Red grape pomace | 50% (w/v) | Homogenizer-assisted | 10,000 rpm, t = 30 s, 15,000 rpm, t = 30 s RL/S = 22.4 mL g−1 | 21.40 | [45] |
Mangosteen pericarp | 99% (w/w) | Stirred-tank | T = 40 °C; t = 24 h, RL/S = 10 mL g−1 | 4.00 | [46] |
Red grape pomace | 32.5% (w/v) | Pressurized-liquid extraction | T = 150 °C; RL/S = 10 mL g−1 | Nr 4 | [47] |
Plant Material | Glycerol Proportion | Extraction Mode | Conditions | Yield in Total Polyphenols (mg GAE g−1) | Reference |
---|---|---|---|---|---|
Hypericum perforatum | 10% (w/v) | Stirred-tank | T = 70 °C; t = 69 min RL/S = 50 mL g−1 | 89.90 | [49] |
Hypericum triquetrifolium Turra | 10% (w/v) | Stirred-tank | T = 70 °C; t = 73 min RL/S = 50 mL g−1 | 54.83 | [50] |
Artemisia arborescens Artemisia inculta Delile | 90% (w/v) | Stirred-tank | T = 80 °C; t = 160 min RL/S = 100 mL g−1 | 48.45 59.91 | [51] |
Salvia triloba (fruticosa) | 40–75% (v/v) | Ultrasound-assisted Pressurized-liquid | T = 25 °C; t = 88 min RL/S = 40 mL g−1 (UAE) | nr | [52] |
Glycyrrhiza glabra | 85% (w/w) | Ultrasound-assisted | T = 70 °C; t = 20 min RL/S = 50 mL g−1 | nr | [53] |
Juglans regia | 20% (w/w) | Stirred-tank | T = 50 °C; t = 120 min RL/S = 33 mL g−1 | 18.30 | [54] |
Origanum onites | 30% (w/v) | Stirred-tank | T = 45 °C; t = 75 min RL/S = 30 mL g−1 | 59.11 | [55] |
Salvia fruticosa Mill. | 60% (w/v) | Stirred-tank, ultrasonication pretreatment | T = 50 °C; t = 150 min RL/S = 25 mL g−1 | 92.00 | [56] |
Origanum vulgare Thymus vulgaris | 95% (w/w) | Maceration | T = 55 °C; t = 10 days RL/S = 19 mL g−1 | 47.85 33.46 | [57] |
Plant Material | HBA | Extraction Mode | Conditions | Yield in Total Polyphenols (mg GAE g−1) | Reference |
---|---|---|---|---|---|
Various plant food wastes | Sodium acetate Sodium-potassium tartrate Choline chloride | Ultrasound-assisted | T = 80 °C; t = 90 min RL/S = 100 mL g−1 | 1.53–88.03 | [69] |
Olive leaves | Sodium-potassium tartrate | Ultrasound-assisted | T = 73 °C; t = 60 min RL/S = 45 mL g−1 | 26.75 | [70] |
Satureja thymbra | Trisodium citrate dihydrate | Stirred-tank | T = 50 °C; t = 200 min RL/S = 45 mL g−1 | 171.48–186.95 | [71] |
Origanum dictamnus | Sodium propionate Sodium butyrate | Stirred-tank | T = 50 °C; t = 200 min RL/S = 45 - 47 mL g−1 | 64.99–76.79 | [73] |
Humulus lupulus | Glycine | Ultrasound-assisted pretreatment Stirred-tank | T = 80 °C; t = 180 min RL/S = 59 mL g−1 | 118.97 | [74] |
Onion solid wastes | Sodium propionate | Stirred-tank | T = 80 °C; t = 150 min RL/S = 100 mL g−1 | 137.50 | [75] |
Moringa oleifera | Nicotinamide | Ultrasound-assisted pretreatment Stirred-tank | T = 80 °C; t = 180 min RL/S = 100 mL g−1 | 82.87 | [76] |
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Makris, D.P.; Lalas, S. Glycerol and Glycerol-Based Deep Eutectic Mixtures as Emerging Green Solvents for Polyphenol Extraction: The Evidence So Far. Molecules 2020, 25, 5842. https://doi.org/10.3390/molecules25245842
Makris DP, Lalas S. Glycerol and Glycerol-Based Deep Eutectic Mixtures as Emerging Green Solvents for Polyphenol Extraction: The Evidence So Far. Molecules. 2020; 25(24):5842. https://doi.org/10.3390/molecules25245842
Chicago/Turabian StyleMakris, Dimitris P., and Stavros Lalas. 2020. "Glycerol and Glycerol-Based Deep Eutectic Mixtures as Emerging Green Solvents for Polyphenol Extraction: The Evidence So Far" Molecules 25, no. 24: 5842. https://doi.org/10.3390/molecules25245842