Next Article in Journal
Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA
Next Article in Special Issue
Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
Previous Article in Journal
Agaricus bisporus Crude Extract: Characterization and Analytical Application
Previous Article in Special Issue
Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 25
Issue 24
10.3390/molecules25245997
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927

by
Alex J. Lee
1,
Melissa M. Cadelis
2,3,
Sang H. Kim
1,
Simon Swift
3,
Brent R. Copp
2 and
Silas G. Villas-Boas
1,*
1
School of Biological Sciences, University of Auckland, 3A Symonds Street, 1010 Auckland, New Zealand
2
School of Chemical Sciences, University of Auckland, 23 Symonds Street, 1010 Auckland, New Zealand
3
School of Medical Sciences, University of Auckland, 85 Park Road, Grafton, 1023 Auckland, New Zealand
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(24), 5997; https://doi.org/10.3390/molecules25245997
Submission received: 31 October 2020 / Revised: 10 December 2020 / Accepted: 16 December 2020 / Published: 18 December 2020
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
Browse Figures
Review Reports Versions Notes

Abstract

We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A—a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV–Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.
Keywords: polyenes; pigment; fungicide; antimicrobial; yeast; antibiotic; bioactives polyenes; pigment; fungicide; antimicrobial; yeast; antibiotic; bioactives

Share and Cite

MDPI and ACS Style

Lee, A.J.; Cadelis, M.M.; Kim, S.H.; Swift, S.; Copp, B.R.; Villas-Boas, S.G. Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927. Molecules 2020, 25, 5997. https://doi.org/10.3390/molecules25245997

AMA Style

Lee AJ, Cadelis MM, Kim SH, Swift S, Copp BR, Villas-Boas SG. Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927. Molecules. 2020; 25(24):5997. https://doi.org/10.3390/molecules25245997

Chicago/Turabian Style

Lee, Alex J., Melissa M. Cadelis, Sang H. Kim, Simon Swift, Brent R. Copp, and Silas G. Villas-Boas. 2020. "Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927" Molecules 25, no. 24: 5997. https://doi.org/10.3390/molecules25245997

APA Style

Lee, A. J., Cadelis, M. M., Kim, S. H., Swift, S., Copp, B. R., & Villas-Boas, S. G. (2020). Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927. Molecules, 25(24), 5997. https://doi.org/10.3390/molecules25245997

Article Metrics

Back to TopTop