Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review
Abstract
:1. Introduction
2. Application of Curcumin for Cancer Therapy
3. Challenges Associated with Curcumin Delivery
4. Biopolymer Nanoparticles (NPs)
4.1. Protein-Based Biopolymers
4.1.1. Albumin
4.1.2. Zein-Based NP
4.1.3. Silk-Based NPs
4.1.4. Other Protein-Based NPs
4.2. Polysaccharide NPs
4.2.1. Chitosan
4.2.2. Alginate
4.2.3. Starch
4.2.4. Cellulose
5. Exosomes
5.1. Advantage and Disadvantage of Exosomes
5.2. Exosomes for Curcumin Delivery
6. Co-Polymers
7. Targeted Delivery
8. Conclusions and Future Trends
Funding
Conflicts of Interest
Abbreviations
VEGF | Vascular endothelial growth factor |
HAS | human serum albumin |
BSA | bovine serum albumin |
NPs | nanoparticles |
HER2 | human epidermal growth factor receptor 2 |
HA | hyaluronic acid |
Apt-HSA/CCM | aptamer-decorated curcumin-loaded human serum albumin |
SSPS | soluble soybean polysaccharide |
Cur-ACRU/CS | curcumin-loaded acylated cruciferin/charged chitosan |
CDG-CANPs | curcumin diethyl diglutarate-loaded Chitosan/alginate NPs |
CUR-AlgNP | curcumin loaded alginate NP |
Cur-CS/Alg NPs | curcumin-loaded chitosan/alginate NPs |
CMC | carboxymethyl cellulose |
Cur-NLCs | curcumin loaded nanostructured lipid carriers |
ANC | aminated nanocellulose |
EWP | egg white protein |
PECs | polyelectrolyte complexes |
SC | sodium caseinate |
SA | sodium alginate |
PEG | poly (ethylene glycol) |
PCL | poly (e-caprolactone) |
FDA | U.S. Food and Drug administration |
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Polymer | Size | Zeta Potential | LC or EE | Cell Line/Animal Model | Advantages | Refs. |
---|---|---|---|---|---|---|
BSA@CUR NPs | 92.59 ± 16.75 nm | −9.19 mV | 18.3% | MCF-7 cells | Increased therapeutic efficacy | [77] |
Curcumin in BSA-dextran NP | 115 nm | 2.8% | Caco-2 cells | Better stability Improve the cellular antioxidant activity of curcumin | [91] | |
Curcumin cross-linked HSA NPs | 125 nm | −12.36 ± 0.73 to −10.88 ± 0.6 mV | was dependent on the particle size | A549 cells | Improved cellular uptake Increased the cytotoxicity | [92] |
Curcumin-loaded zein NPs | 66 nm | +17.1 mV | 7.3 ± 0.1% | GIT model | May be useful for application in functional foods or beverages | [93] |
Curcumin-zein/rhamnolipid complex | 77.29 nm | −31 mV To +3 mV | EE: 98.05% | In vitro simulated gastrointestinal tract | Protect hydrophobic bioactive compounds | [94] |
Pectin-coated CZ NPs | 250 nm to 600 nm | −45 to −50 mV | 5% | Simulated gastrointestinal digestive condition | Enhanced antioxidant activity in an aqueous environment | [95] |
Curcumin-loaded zein NPs with (SC) and (SA) | 190 nm | 17 mV to 19.8 mV | EE: 36.10% to 76.06% | Improving the water solubility Improving photochemical stability improving antioxidant activity | [96] | |
Curcumin-loaded silk fibroin NPs | 155 nm to 170 nm | −45 mV | EE: 50% | Kelly Cells | Higher efficacy in cytotoxicity | [7] |
Curcumin plus SFNs | 71 ± 10 nm | 1.50 ± 0.11 to 11.40 ± 0.76 | In vitro model of osteoarthritis | Exhibited a synergistic antioxidant effect Improve cyto- and hemo-compatibility | [97] | |
CUR-loaded silk NPs | 229 nm to 2286 nm | −17.8 nm to −18.9 mV | 22 to 41% | Rats | Longer plasma circulation time | [98] |
CUR Loaded RBA−CS NPs | 778 nm | Negative | EE: 93.56% | Caco-2 cells | A great potential application for hydrophobic active agent delivery | [99] |
Zein-HA NPs | 186.4 nm | –35.2 to −28.7 mV | 3.66% | Simulate gastrointestinal digestion | Better stability of anti-light degradation, and control release | [100] |
SSPS NPs | 200 nm to 300 nm | EE: 90% | HCT116 and MCF-7 cells | Improved activity Improvement in the anti-proliferative activity | [101] | |
Cur-ACRU/CS NPs | 200 nm to 450 nm | +15 mV | 5.4% | Caco-2 cells | Improved permeability efficiency of free curcumin | [102] |
Cur-Chitosan NPs | 167 nm to 251 nm | + 18.1 to + 20.2 mV | EE: 80% | HaCaT cells | Superior drug release Enhanced transdermal permeation of curcumin A superior percentage of cell viability | [103] |
CDG-CANPs | 215 nm | −24.1 mV | 27% | Caco-2 cells | Improvement of physicochemical stabilities, digestibility, bioaccessibility and cellular uptake | [104] |
CUR-AlgNP | 100-600 nm | −36.0± 0.4 | EE: 68.3% | HeLa and H9c2 | Kills the cancer cell lines at lower concentrations | [105] |
Cur-CS/Alg NPs | 199 nm to 1120 nm | −30.8 mV to −10.8 mV | 0% to 27.4% | HaCaT cells | Improved the cellular uptake of curcumin | [106] |
Starch NPs | < 250 nm | −30 mV | EE: 80% | Simulated gastric and intestinal fluids | Higher encapsulation efficiency | [107] |
OSA starch loaded nano curcumin | 10 nm to 50 nm | HeLa cells | Anti-cancer potential Significant enhancement in cellular uptake Increase bioavailability More controlled release | [108] | ||
Curcumin-load film | 159 ± 31 nm in length and 2 nm in width. | Rat | Improved the regeneration of hair follicles And sebaceous glands of the skin Attenuated the bacterial growth | [109] | ||
Cur- NLCs | 500 nm | EE~58.8 ± 3.5 | Mouse | Reducing the pro-inflammatory cytokine levels in the skin | [110] | |
ANC NPs | ≤150 nm | -31.2 ± 3.66 mV | EE > 90% | L929 and MCF-7 cells | Inhibit microbial growth Prevent preferential killing of cancer cells compared to normal cells | [111] |
WPI-Lac/EGCG NPs | 110 nm | 27 mV | Better protective effect on the breakdown of curcumin in Pickering emulsions More even droplet distribution Greater thermal stability Higher curcumin percentage retention | [112] | ||
CUR-Loaded Gel-mPEG Nanogels | 147 ± 5.2 nm | −12.8 ± 0.6 | 7.9 ± 0.2%, | HeLa cells | Improved solubility Enhanced therapeutic efficacy | [113] |
Curcumin-loaded BSA NPs | 150 nm | Negative | EE: 45% | Murine melanoma model | Increase in survival rate associated with a reduction in tumor size | [114] |
Curcumin loading EWP | 59.25 nm to 431.3 nm | >+30 mV | 11.2 mg/g | Protect the antioxidant activity of encapsulated curcumin | [115] | |
Curcumin-PECs | 264.0 ± 3.1 nm | EE: 53% | HCT116 cells | Induced cell cycle arrest Exhibited cytotoxic effect | [116] |
Polymer | The Route of Targeting | Size | Zeta Potential | LC or EE | Cell Line/Animal Model | Advantages | Refs. |
---|---|---|---|---|---|---|---|
F-CUR-HSANPs | Folate | 165.6 ± 15.7 nm | −27.3 ± 4.2 mV | EE:88.7% ± 4.8% | Murine colon cancer model | Maintained sustained release, and a faster release of CM compare to the unconjugated NPs | [188] |
Apt-HSA/CCM NP | Aptamer to target HER-2 positive cells | 281.1 nm | −33.3 ± 2.5mV | 3.4% | SK-BR3 cells | Higher toxicity | [120] |
Gal-BSA-Cur NPs | Galactosylation to target asialoglycoprotein receptor (ASGPR) overexpressed on hepatocellular carcinoma (HCC) cells | 116.24 nm | −14.12 ± 1.81 | EE:55.47% ± 0.45% | HCC cell line | Enhanced the internalization ability of drug compared with BSA NPs-loaded curcumin | [196] |
Zein and HA for the co-delivery of curcumin and quercetagetin | HA | 231 nm | −30.5 mV | 2.5% | simulated gastrointestinal tract conditions | Improve oral bioavailability | [122] |
Curcumin loaded magnetic silk fibroin core–shell NPs | Magnetic NP | 30 nm to 250 nm | LC: 8.4% | MDA-MB-231 cells | Enhanced growth inhibition | [128] | |
Bi2S3@BSA-FA-CUR | Folic acid | 170.9 nm | −23.2 mV | LC:10 ± 1.51% | The mouse breast carcinoma cell line, Murine breast cancer model | Enhanced the efficacy of chemoradiation therapy | [195] |
magnetic alginate/chitosan layer-by-layer nanoparticles (MACPs) | Fe3O4 NPs | 172 nm to 199 nm | EE: 49.2% | MDA-MB-231 breast cancer cells, HDF cells | The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells | [197] | |
folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system | Fe3O4 NPs | 31.2 ± 2 | 42.9 ± 0.03 | EE: 76.8 ± 0.04% | HepG2 and MCF7 cell lines | Enhanced the uptake by HepG2 cells | [198] |
Cur loaded MnFe2O4–CMC | Fe2O4 NPs | 35 nm | MCF7 and HeLa cells | Enhanced the therapeutic efficacy | [156] |
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Moballegh Nasery, M.; Abadi, B.; Poormoghadam, D.; Zarrabi, A.; Keyhanvar, P.; Khanbabaei, H.; Ashrafizadeh, M.; Mohammadinejad, R.; Tavakol, S.; Sethi, G. Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review. Molecules 2020, 25, 689. https://doi.org/10.3390/molecules25030689
Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Khanbabaei H, Ashrafizadeh M, Mohammadinejad R, Tavakol S, Sethi G. Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review. Molecules. 2020; 25(3):689. https://doi.org/10.3390/molecules25030689
Chicago/Turabian StyleMoballegh Nasery, Mahshid, Banafshe Abadi, Delaram Poormoghadam, Ali Zarrabi, Peyman Keyhanvar, Hashem Khanbabaei, Milad Ashrafizadeh, Reza Mohammadinejad, Shima Tavakol, and Gautam Sethi. 2020. "Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review" Molecules 25, no. 3: 689. https://doi.org/10.3390/molecules25030689