Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Structure–Activity Relationships of 7-Substituted Harmine Analogs
2.3. Effects of Harmine Analogs on Human β-Cell Proliferation
3. Materials and Methods
3.1. Chemistry
3.2. DYRK1A Binding Assays
3.3. β-Cell Proliferation Assay
3.4. Docking
3.5. Electrostatic Potential
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
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Kumar, K.; Wang, P.; A. Swartz, E.; Khamrui, S.; Secor, C.; B. Lazarus, M.; Sanchez, R.; F. Stewart, A.; DeVita, R.J. Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation. Molecules 2020, 25, 1983. https://doi.org/10.3390/molecules25081983
Kumar K, Wang P, A. Swartz E, Khamrui S, Secor C, B. Lazarus M, Sanchez R, F. Stewart A, DeVita RJ. Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation. Molecules. 2020; 25(8):1983. https://doi.org/10.3390/molecules25081983
Chicago/Turabian StyleKumar, Kunal, Peng Wang, Ethan A. Swartz, Susmita Khamrui, Cody Secor, Michael B. Lazarus, Roberto Sanchez, Andrew F. Stewart, and Robert J. DeVita. 2020. "Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation" Molecules 25, no. 8: 1983. https://doi.org/10.3390/molecules25081983