Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System
Abstract
:1. Introduction
2. Results
2.1. Physicochemical Characterization of MOLNBs Formulations
2.2. Hemolytic Activity
2.3. Evaluation of MOLNBs Internalization and Toxicity
2.4. US Monitoring of MOLNBs in the Magnetic Field
3. Discussion
4. Materials and Methods
4.1. Synthesis of SPIONs
4.2. Preparation of MOLNBs Formulations
4.3. Physicochemical Characterization of MOLNBs
4.4. Physical Stability of MOLNBs
4.5. Determination of Hemolytic Activity
4.6. Evaluation of MOLNBs Internalization by Human Brain Microvascular Endothelial Cells
4.7. In Vitro Cytotoxicity Study
4.8. Magnetic Field
4.9. US Imaging Monitoring
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are available from the authors. |
Formulation | Average Diameter (nm) | Polydispersity Index | Zeta Potential (mV) |
---|---|---|---|
Blank OLNBs | 331.6 ± 19.7 | 0.22 ± 0.10 | −35.36 ± 4.16 |
Fluorescent OLNBs | 338.2 ± 13.8 | 0.24 ± 0.08 | −34.24 ± 6.52 |
MOLNBs | 349.2 ± 18.2 | 0.21 ± 0.01 | −20.41 ± 8.60 |
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Ficiarà, E.; Ansari, S.A.; Argenziano, M.; Cangemi, L.; Monge, C.; Cavalli, R.; D’Agata, F. Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System. Molecules 2020, 25, 2104. https://doi.org/10.3390/molecules25092104
Ficiarà E, Ansari SA, Argenziano M, Cangemi L, Monge C, Cavalli R, D’Agata F. Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System. Molecules. 2020; 25(9):2104. https://doi.org/10.3390/molecules25092104
Chicago/Turabian StyleFiciarà, Eleonora, Shoeb Anwar Ansari, Monica Argenziano, Luigi Cangemi, Chiara Monge, Roberta Cavalli, and Federico D’Agata. 2020. "Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System" Molecules 25, no. 9: 2104. https://doi.org/10.3390/molecules25092104