Next Article in Journal
Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts
Next Article in Special Issue
Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro
Previous Article in Journal
Calcium-Dependent Translocation of S100B Is Facilitated by Neurocalcin Delta
Previous Article in Special Issue
Microbiota-Mediated Immune Regulation in Atherosclerosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 26
Issue 1
10.3390/molecules26010229
Review Report
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

Printed Edition

A printed edition of this Special Issue is available at MDPI Books....
share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Anti-Inflammatory Action and Mechanisms of Resveratrol

Molecules 2021, 26(1), 229; https://doi.org/10.3390/molecules26010229
by Tiantian Meng 1, Dingfu Xiao 1,*, Arowolo Muhammed 1, Juying Deng 1, Liang Chen 2 and Jianhua He 1,*
Reviewer 1:
Francesca Oliviero
Reviewer 2: Anonymous
Molecules 2021, 26(1), 229; https://doi.org/10.3390/molecules26010229
Submission received: 10 December 2020 / Revised: 31 December 2020 / Accepted: 31 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Nutraceuticals in Immune Function)

Round 1

Reviewer 1 Report

The paper offers an up-to-date overview on the multiple anti-inflammatory actions of resveratrol. It merely focuses on cellular mechanisms which can be involved in several diseases.

The manuscript is well-structured.

I have only some minor points:

  • Title of fig.1: structure refers to resveratrol. Either the authors add the stilbene chemical structure (for instance as panel a, and then res as b and c), or they modify the title in Structure of trans-resveratrol (a) and cis-resveratrol (b).
  • Line 83, pag 2: polydatin has been demonstrated a very interesting molecule in preventing inflammation. I would suggest to state here that it also the natural precursor of resveratrol.
  • Paragraph 4: I would suggest to move the first sentence (lines 135-137) of subheading 4.1 before it and after paragraph 4 as introductory sentence.
  • Line 152: “resveratrol was able to distinguish” I would suggest to substitute distinguish with another term.. maybe is able to act differently on? What do the author mean with distinguish?
  • Line 167: please add epithelial to A549
  • Figure 2: You should address the title to resveratrol. For ex.: Inhibition of arachidonic acid metabolic pathway by resveratrol.
  • Paragraph 4.2: Line 201-202. I would mention all the 5 members of the NFkB family and eliminate and so on.
  • Paragraph 5: As it represents the final discussion, I would replace this phytoalexin (line 376) with resveratrol, and resveratrol (378) with this phytoalexin.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Reviewed manuscript entitled „Anti-Inflammatory Action and Mechanisms of Resveratrol” submitted by Tiantian Meng et al. is very interesting and summarized information about anti-inflammatory properties of resveratrol.

In my opinion the Authors ought to consider the addition of the table with the content of resveratrol in some food products. Also information about the amount of resveratrol needed for anti-inflammatory activity in human organism could be interesting for readers.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop