Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Compounds
4.2. DPPH Radical Scavenging Assay
4.3. Neuro-2a Cell Culture
4.4. MTT Cell Viability Assay
4.5. Paraquat- and Rotenone-Induced Neurotoxicity
4.6. Lactate Dehydrogenase (LDH) Release Detection
4.7. Reactive Oxygen Species (ROS) Level Analysis
4.8. Data Evaluation
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Compound | % of Radical Scavenging at 100 µM | Compound | % of Radical Scavenging at 100 µM |
---|---|---|---|
1 | 33.1 ± 0.9 | 3 | 41.3 ± 2.1 |
2 | 64.6 ± 1.1 | 4 | 10.3 ± 5.9 |
Ascorbic acid | 67.3 ± 3.4 |
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Yurchenko, E.A.; Menchinskaya, E.S.; Pislyagin, E.A.; Chingizova, E.A.; Girich, E.V.; Yurchenko, A.N.; Aminin, D.L.; Mikhailov, V.V. Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells. Molecules 2021, 26, 3618. https://doi.org/10.3390/molecules26123618
Yurchenko EA, Menchinskaya ES, Pislyagin EA, Chingizova EA, Girich EV, Yurchenko AN, Aminin DL, Mikhailov VV. Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells. Molecules. 2021; 26(12):3618. https://doi.org/10.3390/molecules26123618
Chicago/Turabian StyleYurchenko, Ekaterina A., Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Ekaterina A. Chingizova, Elena V. Girich, Anton N. Yurchenko, Dmitry L. Aminin, and Valery V. Mikhailov. 2021. "Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells" Molecules 26, no. 12: 3618. https://doi.org/10.3390/molecules26123618