Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease
Abstract
:1. Introduction
2. Results
3. Discussion
4. Strengths and Limitations of the Study
5. Materials and Methods
5.1. Study Population and Sample Collection
5.2. Chemicals
5.3. Sample Preparation
5.4. 1H NMR Spectroscopy
5.5. Statistical Analysis
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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BAV | Controls | p-Value | |
---|---|---|---|
Number | 20 | 24 | - |
Age, yrs | 40.1 (18–74) | 42.7 (23–69) | 0.600 |
Males, n (%) | 17 (85) | 14 (58) | 0.055 |
Weight, kg | 75.15 ± 7.47 | 71.8 ± 8.1 | 0.169 |
Height, cm | 175 (152–189) | 177 (158–186) | 0.389 |
BMI, kg/m2 | 24.60 ± 2.48 | 23.36. ± 1.88 | 0.687 |
BSADB, m2 | 1.90 ± 0.12 | 1.79 ± 0.14 | 0.014 |
HR, bpm | 69.95 ± 11.76 | 72.28 ± 11.85 | 0.514 |
Smoking, n (%) | 5 (25) | 6 (25) | 1.00 |
BAV (n = 20) | Controls (n = 24) | p-Value | |
---|---|---|---|
Aortic root | |||
Annulus (mm) | 23.6 (20–26) | 21.83 (19–25) | 0.023 |
Sinuses of Valsalva (mm) | 28.5 (28–34) | 26.12 (25–28) | 0.015 |
Sinotubular junction (mm) | 27.54 ± 3.87 | 25.29 ± 2.31 | 0.024 |
Ascending Aorta (mm) | 28.65 ± 4.3 | 26.20 ± 2.63 | 0.021 |
Left ventricular | |||
ESV index (mL/m2) | 21.85 ± 6.19 | 17.90 ± 3.88 | 0.014 |
EDV index (mL/m2) | 61.95 ± 9.98 | 54.29 ± 10.12 | 0.015 |
SV index (mL/m2) | 39.49 ± 7.67 | 32.83 ± 9.63 | 0.043 |
EF (%) | 61.71 ± 8.44 | 64.04 ± 4.73 | 0.406 |
BAV morphology | |||
Type 1, n (%) | 12 (60) | - | - |
Type 2, n (%) | 8 (40) | - | - |
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Chessa, M.; Panebianco, M.; Corbu, S.; Lussu, M.; Dessì, A.; Pintus, R.; Cesare Marincola, F.; Fanos, V. Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease. Molecules 2021, 26, 4220. https://doi.org/10.3390/molecules26144220
Chessa M, Panebianco M, Corbu S, Lussu M, Dessì A, Pintus R, Cesare Marincola F, Fanos V. Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease. Molecules. 2021; 26(14):4220. https://doi.org/10.3390/molecules26144220
Chicago/Turabian StyleChessa, Massimo, Mario Panebianco, Sara Corbu, Milena Lussu, Angelica Dessì, Roberta Pintus, Flaminia Cesare Marincola, and Vassilios Fanos. 2021. "Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease" Molecules 26, no. 14: 4220. https://doi.org/10.3390/molecules26144220