Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential
Acknowledgments
Conflicts of Interest
References
- Atanasov, A.G.; Zotchev, S.B.; Dirsch, V.M.; The International Natural Product Sciences Taskforce; Supuran, C.T. Natural products in drug discovery: Advances and opportunities. Nat. Rev. Drug Discov. 2021, 20, 200–216. [Google Scholar] [CrossRef] [PubMed]
- Kafi, M.; Koocheki, A.; Rashed, M.H.; Nassiri, M. (Eds.) Saffron (Crocus sativus) Production and Processing, 1st ed.; Science Publishers: Washington, DC, USA, 2016; ISBN 978-1-57808-427-2. [Google Scholar]
- Pitsikas, N. Crocus sativus L. Extracts and Its Constituents Crocins and Safranal; Potential Candidates for Schizophrenia Treatment? Nikolaos Pitsikas Mol. 2021, 26, 1237. [Google Scholar] [CrossRef]
- Lambrianidou, A.; Koutsougianni, F.; Papapostolou, I.; Dimas, K. Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents. Molecules 2020, 26, 86. [Google Scholar] [CrossRef] [PubMed]
- Amin, A.; Farrukh, A.; Murali, C.; Soleimani, A.; Praz, F.; Graziani, G.; Brim, H.; Ashktorab, H. Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability. Molecules 2021, 26, 3855. [Google Scholar] [CrossRef] [PubMed]
- Banskota, S.; Brim, H.; Kwon, Y.H.; Singh, G.; Sinha, S.R.; Wang, H.; Khan, W.I.; Ashktorab, H. Saffron Pre-Treatment Pro-motes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice. Molecules 2021, 26, 3351. [Google Scholar] [CrossRef] [PubMed]
- Pitsikas, N.; Tarantilis, P. Crocins, the Bioactive Components of Crocus sativus L., Counteract the Disrupting Effects of Anesthetic Ketamine on Memory in Rats. Molecules 2021, 26, 528. [Google Scholar] [CrossRef] [PubMed]
- Pitsikas, N.; Tarantilis, P.A. The GABAA-Benzodiazepine Receptor Antagonist Flumazenil Abolishes the Anxiolytic Effects of the Active Constituents of Crocus sativus L. Crocins in Rats. Molecules 2020, 25, 5647. [Google Scholar] [CrossRef] [PubMed]
- Orio, L.; Alen, F.; Ballesta, A.; Martin, R.; Gomez de Heras, R. Antianhedonic and Antidepressant Effects of Affron®, a Standardized Saffron (Crocus sativus L.) Extract. Molecules 2020, 25, 3207. [Google Scholar] [CrossRef] [PubMed]
- Maggi, M.A.; Bisti, S.; Picco, C. Saffron: Chemical Composition and Neuroprotective Activity. Molecules 2020, 25, 5618. [Google Scholar] [CrossRef] [PubMed]
- Rossi, G.; Placidi, M.; Castellini, C.; Rea, F.; D’Andrea, S.; Alonso, G.L.; Gravina, G.L.; Tatone, C.; Di Emidio, G.; D’Alessandro, A.M. Crocetin Mitigates Irradiation Injury in an In Vitro Model of the Pubertal Testis: Focus on Biological Effects and Molecular Mechanisms. Molecules 2021, 26, 1676. [Google Scholar] [CrossRef] [PubMed]
- Kakouri, E.; Agalou, A.; Kanakis, C.; Beis, D.; Tarantilis, P.A. Crocins from Crocus sativus L. in the Management of Hyper-glycemia. In Vivo Evidence from Zebrafish. Molecules 2020, 25, 5223. [Google Scholar] [CrossRef] [PubMed]
- Gikas, E.; Koulakiotis, N.S.; Tsarbopoulos, A. Phytochemical Differentiation of Saffron (Crocus sativus L.) by High Resolution Mass Spectrometry Metabolomic Studies. Molecules 2021, 26, 2180. [Google Scholar] [CrossRef] [PubMed]
- Girme, A.; Pawar, S.; Ghule, C.; Shengule, S.; Saste, G.; Balasubramaniam, A.K.; Deshmukh, A.; Hingorani, L. Bioanalytical Method Development and Validation Study of Neuroprotective Extract of Kashmiri Saffron Using Ultra-Fast Liquid Chroma-tography-Tandem Mass Spectrometry (UFLC-MS/MS): In Vivo Pharmacokinetics of Apocarotenoids and Carotenoids. Molecules 2021, 26, 1815. [Google Scholar] [CrossRef]
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Pitsikas, N.; Dimas, K. Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential. Molecules 2021, 26, 4226. https://doi.org/10.3390/molecules26144226
Pitsikas N, Dimas K. Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential. Molecules. 2021; 26(14):4226. https://doi.org/10.3390/molecules26144226
Chicago/Turabian StylePitsikas, Nikolaos, and Konstantinos Dimas. 2021. "Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential" Molecules 26, no. 14: 4226. https://doi.org/10.3390/molecules26144226