Biopharmaceutical Study on Nobiletin-Loaded Amorphous Solid Dispersion with Improved Hypouricemic Effect
Abstract
:1. Introduction
2. Results and Discussion
2.1. Appearance and Crystallinity of NOB Samples
2.2. Dissolution Testing of NOB Samples
2.3. Pharmacokinetic Study of NOB Samples
2.4. Hypouricemic Effects of NOB Samples in Rats
3. Material and Methods
3.1. Chemicals
3.2. Preparation for ASD Formulation of NOB
3.3. NOB Determination
3.4. Microscopic Experiments
3.5. Crystallinity
3.6. Dissolution Test
3.7. Pharmacokinetic Studies
3.7.1. Animals and Drug Administration
3.7.2. Plasma Concentration of NOB
3.8. Pharmacodynamic Studies
3.8.1. Rat Model of Hyperuricemia
3.8.2. Measurement of Uric Acid
3.9. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
Sample Availability
Abbreviations
References
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Cmax (μg/mL) | Tmax (h) | AUC0–24 (μg·h/mL) | BA (%) | |
---|---|---|---|---|
Crystalline NOB (50 mg/kg) | 0.087 ± 0.029 | 3.0 ± 0.58 | 0.23 ± 0.086 | 0.20 ± 0.072 |
ASD/NOB (50 mg-NOB/kg) | 1.2 ± 0.16 | 1.2 ± 0.15 | 4.1 ± 0.80 | 3.5 ± 0.67 |
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Nihei, T.; Ushiro, E.; Sato, H.; Onoue, S. Biopharmaceutical Study on Nobiletin-Loaded Amorphous Solid Dispersion with Improved Hypouricemic Effect. Molecules 2021, 26, 4447. https://doi.org/10.3390/molecules26154447
Nihei T, Ushiro E, Sato H, Onoue S. Biopharmaceutical Study on Nobiletin-Loaded Amorphous Solid Dispersion with Improved Hypouricemic Effect. Molecules. 2021; 26(15):4447. https://doi.org/10.3390/molecules26154447
Chicago/Turabian StyleNihei, Takuya, Eri Ushiro, Hideyuki Sato, and Satomi Onoue. 2021. "Biopharmaceutical Study on Nobiletin-Loaded Amorphous Solid Dispersion with Improved Hypouricemic Effect" Molecules 26, no. 15: 4447. https://doi.org/10.3390/molecules26154447