Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Abstract
:1. Introduction
2. Results and Discussion
2.1. MIC
2.2. Time-Kill Test
2.3. 5-Alpha Reductase Gene Expression
2.4. Clinical Trials (Sebumetry, Porphyrins, Inflammatory Lesions, Face Skin’s General Aspect/Appearance and Perceived Efficacy by Dermatologist)
3. Material and Methods
3.1. Minimum Inhibitory Concentration (MIC)
3.2. Time-Kill Test
3.3. Evaluation of 5-Alpha Reductase Gene Expression
3.4. Clinical Trials
3.4.1. Participants and Application Protocol of the Samples
3.4.2. Sebumetry Measurement
3.4.3. Porphyrins, Inflammatory Lesions and Face Skin’s General Aspect/Appearance
3.4.4. Perceived Efficacy by Dermatologist
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Ingredients | % (w/w) | ||
---|---|---|---|
Placebo (Blank Sample) | PXCA 19007 0.5% | PXCA 19007 1.0% | |
Cetearyl Alcohol (and) Polysorbate 60 (Uniox® C) (Chemyunion, Sorocaba, Brazil) | 12.00 | 12.00 | 12.00 |
Aqua | 87.40 | 86.90 | 86.40 |
Propanediol (and) Caprylic Acid (and) Xylitol (PXCA) (Chemyunion, Sorocaba, Brazil) | - | 0.50 | 1.00 |
Phenoxyethanol (Merck, São Paulo, Brazil) | 0.35 | 0.35 | 0.35 |
Potassium Sorbate (Merck, São Paulo, Brazil) | 0.25 | 0.25 | 0.25 |
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Mussi, L.; Baby, A.R.; Camargo Junior, F.B.; Padovani, G.; Sufi, B.d.S.; Magalhães, W.V. Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays. Molecules 2021, 26, 6704. https://doi.org/10.3390/molecules26216704
Mussi L, Baby AR, Camargo Junior FB, Padovani G, Sufi BdS, Magalhães WV. Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays. Molecules. 2021; 26(21):6704. https://doi.org/10.3390/molecules26216704
Chicago/Turabian StyleMussi, Lilian, André Rolim Baby, Flavio Bueno Camargo Junior, Giovana Padovani, Bianca da Silva Sufi, and Wagner Vidal Magalhães. 2021. "Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays" Molecules 26, no. 21: 6704. https://doi.org/10.3390/molecules26216704