The Role of the Inflammasome in Neurodegenerative Diseases
Abstract
:1. Introduction
2. Alzheimer’s Disease
3. Multiple Sclerosis
4. Parkinson’s Disease
5. Amyotrophic Lateral Sclerosis
6. Pharmacological Modulation of the Inflammasome
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Disease | System | Inflammasome Component/Effector | References |
---|---|---|---|
Alzheimer’s | Human | ↑ IL-1β, ↑ IL-18 ↑ NLRP1, ↑ ASC, ↑ caspase-1 ↑ NLRP3, ↑ IL-1β | Awad et al., 2017 [16] Heneka et al., 2013 [17] La Rosa et al., 2017 [18] Saresella et al., 2017 [19] Kaushal et al., 2015 [26] Cattaneo et al., 2016 [40] |
Multiple Sclerosis | Human | ↑ NLRP3, ↑ IL-1β, ↑caspase-1 ↑ caspase-1, ↑ IL-1β ↑ caspase-1 ↑ IL-18 ↑ IL-1β ↑ NLRP3, ↑ ASC, ↑ IL-18, ↑ caspase-8 | Peleen et al., 2015 [46] Inoue & Shinohara, 2013 [47] Mamik&Power, 2017 [48] Furlan R et al., 1999 [49] Ming X et al., 2002 [50] Losy J et al., 2001 [52] Nicoletti F et al., 2001 [53] Chen YC et al., 2012 [54] Gris D et al., 2010 [44] de Jong et al., 2002 [55] Piancone et al., 2018 [62] |
Parkinson’s Disease | Human | ↑ IL-1β ↑ IL-1β, ↑ IL-18 ↑ IL-1β, ↑ caspase-1 ↑ NLRP3, ↑ IL-1β, ↑ caspase-1 | Codolo et al., 2013 [71] Zhang et al., 2016 [77] Zhou Y et al., 2015 [74] Fan et al., 2020 [78] |
Amyotrophic Lateral Sclerosis | Human | ↑ IL-18 ↑ NLRP3, ↑ ASC, ↑ IL-18, ↑ caspase-1 ↑ NLRP3, ↑ caspase-1 | Italiani et al., 2014 [85] Johann et al., 2015 [84] Kadhim et al., 2016 [86] |
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Piancone, F.; La Rosa, F.; Marventano, I.; Saresella, M.; Clerici, M. The Role of the Inflammasome in Neurodegenerative Diseases. Molecules 2021, 26, 953. https://doi.org/10.3390/molecules26040953
Piancone F, La Rosa F, Marventano I, Saresella M, Clerici M. The Role of the Inflammasome in Neurodegenerative Diseases. Molecules. 2021; 26(4):953. https://doi.org/10.3390/molecules26040953
Chicago/Turabian StylePiancone, Federica, Francesca La Rosa, Ivana Marventano, Marina Saresella, and Mario Clerici. 2021. "The Role of the Inflammasome in Neurodegenerative Diseases" Molecules 26, no. 4: 953. https://doi.org/10.3390/molecules26040953