Next Article in Journal
Matrix-Assisted DOSY for Analysis of Indole Alkaloid Mixtures
Previous Article in Journal
A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity
Previous Article in Special Issue
Opening up the Toolbox: Synthesis and Mechanisms of Phosphoramidates
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 26
Issue 6
10.3390/molecules26061750
Review Report
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Thiol-ene Reaction: An Efficient Tool to Design Lipophilic Polyphosphoesters for Drug Delivery Systems

Molecules 2021, 26(6), 1750; https://doi.org/10.3390/molecules26061750
by Stéphanie Vanslambrouck 1, Raphaël Riva 1, Bernard Ucakar 2, Véronique Préat 2, Mick Gagliardi 3, Daniel G. M. Molin 3, Philippe Lecomte 1 and Christine Jérôme 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Molecules 2021, 26(6), 1750; https://doi.org/10.3390/molecules26061750
Submission received: 1 March 2021 / Revised: 16 March 2021 / Accepted: 17 March 2021 / Published: 20 March 2021
(This article belongs to the Special Issue Phosphorus-Containing Materials and Polymers: How a Central Element of All Living Matter can be Used in the Synthetic World)

Round 1

Reviewer 1 Report

Jérôme and coworkers reported the synthesis of poly(phosphoesters) and its functionalization via thiol-ene reaction. Several issues are suggested to be addressed. 

  1. The structure of PEG-b-PTocoS-BEP in Scheme 1 should be revised. The current version indicates that the unconjugated and conjugated alkene units belong to the same block, meaning that there is a fixed orientation. In fact, the thiol-ene reaction on PEG-b-PBenZP is expected to result in the unreacted alkene and Toco-conjugation statistically distributed. Please revise.
  2. Line 164 cited a reference to prove the impurity within the starting material. It is more convincing to run a GPC for the starting material (MeO-PEO-OH) and show this evidence in the supporting information.
  3. In Table 1, does longer irradiation time result in higher yield for the toco-conjugation, e.g. 2 hours?
  4. Characterization (NMR, GPC, etc.) for PEG-b-PButEP, PEG-b-PBenEP, are PEG-b-PHEP is missing. 
  5. The unit for polymer concentration is suggested to be revised to mg/mL or μg/mL (IUPAC suggestion: https://iupac.org/cms/wp-content/uploads/2016/01/Compendium-of-Polymer-Terminology-and-Nomenclature-IUPAC-Recommendations-2008.pdf). Figure 6 can indeed benefit from such revisions. 
  6.  What is the drug release mechanism and drug release kinetics of these polymeric micelles? Please provide the data. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This is a well-written manuscript about the preparation of a novel diblock copolymer-based drug delivery system. 

The only question of the reviewer is related to the bimodal SEC traces of the copolymers. According to the authors, the small peak at low elution volumes corresponds to the presence of PPE-PEG-PPE triblock copolymers. Can the authors estimate the amount of this fraction in the preparations? What happens with the triblock copolymer when the samples are dispersed in water? Do these polymers form co-micelles or separate micelles? Can this heterogeneity be observed on DLS or TEM?

Minor points: Please check/correct the sentences at lines 39 and 77. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop