Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Mouse Single-Prolonged Stress (mSPS)
4.3. Chronic Intermittent Ethanol (CIE) Vapor Exposure
4.4. Brain Tissue Dissection
4.5. AEA and 2-AG Extraction for UHPLC-MS/MS Analysis
4.6. UHPLC-MS/MS
4.7. Protein Extraction for Immunoblot Analysis
4.8. Immunoblotting
4.9. Data Analysis and Statistics
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Piggott, V.M.; Lloyd, S.C.; Matchynski, J.I.; Perrine, S.A.; Conti, A.C. Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain. Molecules 2021, 26, 2086. https://doi.org/10.3390/molecules26072086
Piggott VM, Lloyd SC, Matchynski JI, Perrine SA, Conti AC. Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain. Molecules. 2021; 26(7):2086. https://doi.org/10.3390/molecules26072086
Chicago/Turabian StylePiggott, Veronica M., Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, and Alana C. Conti. 2021. "Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain" Molecules 26, no. 7: 2086. https://doi.org/10.3390/molecules26072086