Next Article in Journal
Interaction of Squid (Dosidicus giga) Mantle Protein with a Mixtures of Potato and Corn Starch in an Extruded Snack, as Characterized by FTIR and DSC
Next Article in Special Issue
Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
Previous Article in Journal
β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 26
Issue 7
10.3390/molecules26072102
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

by
Sophie Hoenke
1,
Martin A. Christoph
1,
Sander Friedrich
1,
Niels Heise
1,
Benjamin Brandes
1,
Hans-Peter Deigner
2,
Ahmed Al-Harrasi
3 and
René Csuk
1,*
1
Organic Chemistry, Martin–Luther University Halle–Wittenberg, Kurt–Mothes, Str. 2, D-06120 Halle (Saale), Germany
2
Institute of Precision Medicine, Medical and Life Science Faculty, Furtwangen University, Jakob–Kienzle–Str. 17, D-78054 Villigen–Schwenningen, Germany
3
Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkat Al-Mauz, PC 616 Nizwa, Oman
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(7), 2102; https://doi.org/10.3390/molecules26072102
Submission received: 12 March 2021 / Revised: 29 March 2021 / Accepted: 4 April 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Triterpenoids and Derivatives with Anticancer Activity)
Browse Figures
Versions Notes

Abstract

Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC50 = 0.6 μM for HT29 colon adenocarcinoma cells).
Keywords: oleanolic acid; ursolic acid; betulinic acid; platanic acid; 1,4-cyclohexyldiamines; cytotoxicity oleanolic acid; ursolic acid; betulinic acid; platanic acid; 1,4-cyclohexyldiamines; cytotoxicity
Graphical Abstract

Share and Cite

MDPI and ACS Style

Hoenke, S.; Christoph, M.A.; Friedrich, S.; Heise, N.; Brandes, B.; Deigner, H.-P.; Al-Harrasi, A.; Csuk, R. The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids. Molecules 2021, 26, 2102. https://doi.org/10.3390/molecules26072102

AMA Style

Hoenke S, Christoph MA, Friedrich S, Heise N, Brandes B, Deigner H-P, Al-Harrasi A, Csuk R. The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids. Molecules. 2021; 26(7):2102. https://doi.org/10.3390/molecules26072102

Chicago/Turabian Style

Hoenke, Sophie, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, and René Csuk. 2021. "The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids" Molecules 26, no. 7: 2102. https://doi.org/10.3390/molecules26072102

APA Style

Hoenke, S., Christoph, M. A., Friedrich, S., Heise, N., Brandes, B., Deigner, H.-P., Al-Harrasi, A., & Csuk, R. (2021). The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids. Molecules, 26(7), 2102. https://doi.org/10.3390/molecules26072102

Article Metrics

Back to TopTop