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Volume 26
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Review

Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives

by
Larisa V. Zhilitskaya
,
Bagrat A. Shainyan
* and
Nina O. Yarosh
E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(8), 2190; https://doi.org/10.3390/molecules26082190
Submission received: 17 March 2021 / Revised: 4 April 2021 / Accepted: 9 April 2021 / Published: 10 April 2021
(This article belongs to the Special Issue Feature Review Papers in Organic Synthesis)
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Abstract

The review is devoted to modern trends in the chemistry of 2-amino and 2-mercapto substituted benzothiazoles covering the literature since 2015. The reviewed heterocycles belong to biologically active and industrially demanded compounds. Newly developed synthesis methods can be divided into conventional multistep processes and one-pot, atom economy procedures, realized using green chemistry principles and simple reagents. The easy functionalization of the 2-NH2 and 2-SH groups and the benzene ring of the benzothiazole moiety allows considering them as highly reactive building blocks for organic and organoelement synthesis, including the synthesis of pharmacologically active heterocycles. The review provides a summary of findings, which may be useful for developing new drugs and materials and new synthetic approaches and patterns of reactivity.
Keywords: benzothiazole; 2-aminobenzothiazole; 2-mercaptobenzothiazole; synthesis; reactivity; biological activity benzothiazole; 2-aminobenzothiazole; 2-mercaptobenzothiazole; synthesis; reactivity; biological activity

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MDPI and ACS Style

Zhilitskaya, L.V.; Shainyan, B.A.; Yarosh, N.O. Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives. Molecules 2021, 26, 2190. https://doi.org/10.3390/molecules26082190

AMA Style

Zhilitskaya LV, Shainyan BA, Yarosh NO. Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives. Molecules. 2021; 26(8):2190. https://doi.org/10.3390/molecules26082190

Chicago/Turabian Style

Zhilitskaya, Larisa V., Bagrat A. Shainyan, and Nina O. Yarosh. 2021. "Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives" Molecules 26, no. 8: 2190. https://doi.org/10.3390/molecules26082190

APA Style

Zhilitskaya, L. V., Shainyan, B. A., & Yarosh, N. O. (2021). Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives. Molecules, 26(8), 2190. https://doi.org/10.3390/molecules26082190

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