Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental Section
3.1. General Procedure
3.1.1. General Procedure for Synthesis of Brominated Azatetracyclic Derivatives, 2a–d and 3a–c under Conventional TH Conditions and US Irradiation
3.1.2. General Procedure for Synthesis of Functionalized Azatetracyclic Derivatives, 4a–d under Conventional TH Conditions and US Irradiation
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Compound | Ultrasounds | Conventional TH | ||
---|---|---|---|---|
Reaction Time, (h) | Yield, % | Reaction Time, (h) | Yield, % | |
2a | 1 | 87 | 24 | 52 |
2b | 1 | 74 | 24 | 46 |
2c | 1 | 85 | 24 | 53 |
2d | 1 | 70 | 24 | 54 |
3a | 1 | 0 | 24 | 10 |
3b | 1 | 0 | 24 | 15 |
3c | 1 | 0 | 24 | 11 |
Compound | Ultrasounds | Room Temperature Stirring | ||
---|---|---|---|---|
Reaction Time, (h) | Yield, % | Reaction Time, (h) | Yield, % | |
4a | 2 | 93 | 48 | 82 |
4b | 2 | 86 | 48 | 70 |
4c | 2 | 95 | 48 | 83 |
4d | 2 | 83 | 48 | 68 |
Compound | Fluorescence (λmax, nm) | Absorption (λmax, nm) | Quantum Yields (%) |
---|---|---|---|
2a | 443 | 394 | 22.11 |
2b | 431 | 391 | 18.64 |
2c | 444 | 412 | 15.92 |
2d | 433 | 393 | 17.09 |
4a | 430 | 406 | 9.34 |
4b | 435 | 387 | 7.17 |
4c | 430 | 409 | 8.99 |
4d | 445 | 393 | 5.30 |
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Zbancioc, G.; Ciobanu, C.-I.; Mangalagiu, I.I.; Moldoveanu, C. Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach. Molecules 2022, 27, 3180. https://doi.org/10.3390/molecules27103180
Zbancioc G, Ciobanu C-I, Mangalagiu II, Moldoveanu C. Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach. Molecules. 2022; 27(10):3180. https://doi.org/10.3390/molecules27103180
Chicago/Turabian StyleZbancioc, Gheorghita, Catalina-Ionica Ciobanu, Ionel I. Mangalagiu, and Costel Moldoveanu. 2022. "Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach" Molecules 27, no. 10: 3180. https://doi.org/10.3390/molecules27103180