Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer
Abstract
:1. Introduction
2. Results and Discussions
2.1. Preparation and Characterization of BP@SF Sheets
2.2. Preparation and Characterization of BP@SF Electrospun Membranes
2.3. Hydrophilic and Hydrophobic Properties
2.4. Tensile Properties
2.5. Photothermal Effects and Stability Tests
2.6. Biocompatibility
2.7. In Vitro Anti-Tumor Properties
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Preparation of BP Nanosheets
4.2.1. Preparation of SF Aqueous Solutions
4.2.2. Preparation of BP@SF
4.3. Preparation of SF/PLGA/BP@SF Electrospun Composite Membranes
4.4. Characterizations of BP@SF
4.5. Characterizations of SF/PLGA/BP@SF Electrospun Composite Membranes
4.6. Photothermal Effect Measurement
4.7. Cell Culture
4.8. Biocompatibility Test
4.9. In Vitro Anti-Tumor Performance Testing
4.10. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Sample | Atomic Conc. | Weight Conc. |
---|---|---|
SF/PLGA | 0.06% | 0.13% |
SF/PLGA/BP@SF-1 | 0.06% | 0.14% |
SF/PLGA/BP@SF-2 | 0.08% | 0.18% |
SF/PLGA/BP@SF-4 | 0.11% | 0.25% |
Element Number | Element Symbol | Element Name | Atomic Conc. | Weight Conc. |
---|---|---|---|---|
6 | C | Carbon | 43.45% | 37.82% |
8 | O | Oxygen | 32.02% | 37.13% |
7 | N | Nitrogen | 24.42% | 24.79% |
15 | P | Phosphorus | 0.11% | 0.25% |
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Li, X.; Zhou, J.; Wu, H.; Dai, F.; Li, J.; Li, Z. Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer. Molecules 2022, 27, 4563. https://doi.org/10.3390/molecules27144563
Li X, Zhou J, Wu H, Dai F, Li J, Li Z. Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer. Molecules. 2022; 27(14):4563. https://doi.org/10.3390/molecules27144563
Chicago/Turabian StyleLi, Xia, Jiale Zhou, Haiyan Wu, Fangyin Dai, Jiashen Li, and Zhi Li. 2022. "Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer" Molecules 27, no. 14: 4563. https://doi.org/10.3390/molecules27144563