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Review

A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia

by
Wojciech Ziemichód
*,
Karolina Grabowska
,
Antonina Kurowska
and
Grażyna Biała
Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(18), 6041; https://doi.org/10.3390/molecules27186041
Submission received: 24 August 2022 / Revised: 11 September 2022 / Accepted: 12 September 2022 / Published: 16 September 2022
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Abstract

Insomnia affects 4.4–4.8% of the world’s population, but because the effect of hypnotic drugs is limited and may cause harmful side-effects, scientists are turning their attention to developing drugs that act on the orexin system. Daridorexant, a selective dual-orexin receptor antagonist (DORA), has exhibited promising results in both animal and human studies. Its activity was evaluated based on the physiology-based pharmacodynamic and pharmacokinetic model. The use of daridorexant is considered safe, with no clinically significant side-effects including deprivation of next-morning residual effects. In this manuscript we conducted a comprehensive review of daridorexant including pharmacodynamics, animal and human research, pharmacokinetics and safety.
Keywords: daridorexant; insomnia; DORA; orexin system; orexin antagonists daridorexant; insomnia; DORA; orexin system; orexin antagonists

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MDPI and ACS Style

Ziemichód, W.; Grabowska, K.; Kurowska, A.; Biała, G. A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia. Molecules 2022, 27, 6041. https://doi.org/10.3390/molecules27186041

AMA Style

Ziemichód W, Grabowska K, Kurowska A, Biała G. A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia. Molecules. 2022; 27(18):6041. https://doi.org/10.3390/molecules27186041

Chicago/Turabian Style

Ziemichód, Wojciech, Karolina Grabowska, Antonina Kurowska, and Grażyna Biała. 2022. "A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia" Molecules 27, no. 18: 6041. https://doi.org/10.3390/molecules27186041

APA Style

Ziemichód, W., Grabowska, K., Kurowska, A., & Biała, G. (2022). A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia. Molecules, 27(18), 6041. https://doi.org/10.3390/molecules27186041

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