Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Nanofiber Membrane
2.3. Characterization
2.4. In Vitro Drug Release Test
2.5. In Vitro Biocompatibility Test
3. Results and Discussion
3.1. Property Characterization of Spinning Solutions
3.2. Morphology Analysis of SIM and SA/SIM Particles
3.3. Morphology Characterization of NFMs
3.4. Fourier Transform Infrared (FTIR) Analysis
3.5. Mechanical Properties of NFMs
3.6. Wetting Properties of Nanofiber Membranes
3.7. Analysis of Drug Release Performance
3.8. Biocompatibility of NMFs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Electrospun NFM Code | Spinning Solution Composition |
---|---|
NO.0 | 25 wt% PCL/PEG (PCL:PEG = 8:2) |
NO.1 | 25 wt% PCL/PEG (PCL:PEG = 8:2) 0.16 g SIM |
NO.2 | 25 wt% PCL/PEG (PCL:PEG = 8:2) 5 wt% SIM/3 wt% SA containing 0.16 g SIM |
Spinning Solution Code | Viscositiy (mPa.S) | Conductitivity (μS/cm) |
---|---|---|
NO.0 | 307 | 7.79 |
NO.1 | 275 | 8.15 |
NO.2 | 126 | 14.19 |
NFM | Thickness (mm) | Young’s Modulus (MPa) | Fracture Strength (MPa) | Elongation at Break (%) |
---|---|---|---|---|
NO.0 | 0.11 ± 0.03 | 0.10 ± 0.09 | 0.93 ± 0.05 | 35.27 ± 3.98 |
NO.1 | 0.16 ± 0.04 | 0.09 ± 0.07 | 0.85 ± 0.09 | 31.04 ± 1.76 |
NO.2 | 0.11 ± 0.03 | 0.06 ± 0.07 | 1.24 ± 0.03 | 43.89 ± 2.15 |
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Pan, L.; Yang, J.; Xu, L. Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release. Molecules 2022, 27, 7158. https://doi.org/10.3390/molecules27217158
Pan L, Yang J, Xu L. Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release. Molecules. 2022; 27(21):7158. https://doi.org/10.3390/molecules27217158
Chicago/Turabian StylePan, Lu, Jiahao Yang, and Lan Xu. 2022. "Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release" Molecules 27, no. 21: 7158. https://doi.org/10.3390/molecules27217158
APA StylePan, L., Yang, J., & Xu, L. (2022). Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release. Molecules, 27(21), 7158. https://doi.org/10.3390/molecules27217158