The Chemical Property Position of Bedaquiline Construed by a Chemical Global Positioning System-Natural Product

Round 1

Reviewer 1 Report

In this manuscript Alajlani and Backlund describes the comparison of Bedaquiline to other antituberculosis compounds by ChemGPS. The traditional approach of drug discovery is time consuming and only a small percent molecules reaches clinical trials. That's why every new computational methods that help in preliminary screening is really important. Using Bedaquiline as a model compound the authors demonstrated that using physico chemical similarity instead of traditional chemical similarity can indeed be a helpful method of searching for new drug candidates.

The preparation of the manuscript is a bit sloppy, there are many typos and grammatical mistakes.

Author Response

Thank you very much for your positive feedback. We are indeed grateful for your time and notes.

We apologize for typos errors and grammar mistakes. All typos are corrected and the article was checked by native speaker Professor Jeff Elhi for overall English improvement.

Thank you again for reviewing our manuscript.

Authors

Reviewer 2 Report

The Paper is suitable for publication after considering an intensive English proof read.

Few points below  need to be corrected

Line 155, what are the names of basic drugs used?

What is the Ref of part 3.2?

What is the Ref of part 3,6?

Author Response

Thank you very much for your notes. We appreciate the time and effort going through the manuscript.

Every point mentioned was considered in the revision:

>The manuscript is now revised extensively for any language issues and typos errors etc.

>The names of basic drugs were incorporated and the whole sentence was rephrased for more clearer indication.

> References were added.

Best regards and Happy holidays