Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer
Abstract
:1. Introduction
2. Light-Responsive Nanocarriers
3. Ultrasound-Responsive Nanocarriers
4. PH-Responsive Nanocarriers
5. Enzyme-Responsive Nanocarriers
6. Discussion and Perspective
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Stimuli | Specific Conditions | Nanocarriers | Diagnostic /Imaging | Therapeutics | Reference |
---|---|---|---|---|---|
Light | Near-infrared (NIR) light | Gold nanocage@manganese dioxide (AuNC@MnO2) nanoparticles | √ | √ | Lee et al., 2019 |
Titania-coated gold nanobipyramids | √ | Chen et al., 2019 | |||
Poly(l-lysine)-conjugated chlorin e6 (Ce6) derivative nanoparticle | √ | Zhang et al., 2020 | |||
Palladium nanosheet (PdNS) | √ | Wang et al., 2018 | |||
Semiconducting polymer nanoadjuvant (SPNIIIR) | √ | Li et al., 2021 | |||
CE7Q/CQ/S | √ | √ | Li et al., 2020 | ||
Short-wavelength and NIR light | O-nitrobenzyl ester modified polymersome with up-conversion nanoparticles | √ | Tsai et al., 2021 | ||
Ultrasound | Mechanical effect | Perfluoropentane containing nanobubbles | √ | Baspinar et al., 2019 | |
Chemical effect | PEGylated Co2Fe2O4 nanoflowers (CFP) | √ | √ | Fu et al., 2021 | |
Synergistically therapeutic modality | Cerasomal perfluorocarbon nanodroplet (D-vPCs-O2) | √ | √ | Ma et al., 2020 | |
EXO-DVDMS | √ | √ | Liu et al., 2019 | ||
Liposome-based nanobubbles | √ | √ | Lee et al., 2017; | ||
pH | pH 5.7–6.9 | CHEMS-based liposomes; HA-ERL/BEV-LPH nanoparticles; DOX-loaded mixed micelles; DA-TAT carrier; mPEG-PHis-PSD; U11-DOX/CUR nanoparticles; Cis-aconitic anhydride-modified doxorubicin | √ | Park et al., 2021; Pang et al., 2020; Shih et al., 2020; Jing et al., 2018; Shi et al., 2018; Hong et al., 2019; Xia et al., 2018 | |
Enzyme | MMP-2 | Cur-P-NPs | √ | Han et al., 2017 | |
MMP-9 | MMP-9-sensitive nanocarrier | √ | Sidi et al., 2019 | ||
MMPs | A smart inhalable nanocarrier | √ | Vaghasiya et al., 2021 | ||
HAase | HPGBCA | √ | Ren et al., 2019 | ||
Esterase | Gold nanorod–curcumin conjugate, HAPBA | √ | Zhu et al., 2018; Lee et al., 2019 | ||
NQO1 | QPA-P | √ | Park et al., 2021 |
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Lin, X.; Wu, J.; Liu, Y.; Lin, N.; Hu, J.; Zhang, B. Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer. Molecules 2022, 27, 948. https://doi.org/10.3390/molecules27030948
Lin X, Wu J, Liu Y, Lin N, Hu J, Zhang B. Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer. Molecules. 2022; 27(3):948. https://doi.org/10.3390/molecules27030948
Chicago/Turabian StyleLin, Xu, Jiahe Wu, Yupeng Liu, Nengming Lin, Jian Hu, and Bo Zhang. 2022. "Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer" Molecules 27, no. 3: 948. https://doi.org/10.3390/molecules27030948