Next Article in Journal
Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
Next Article in Special Issue
β-Cyclodextrin as the Key Issue in Production of Acceptable Low-Cholesterol Dairy Products
Previous Article in Journal
Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms
Previous Article in Special Issue
Synthesis of Mono-Amino Substituted γ-CD: Host–Guest Complexation and In Vitro Cytotoxicity Investigation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 27
Issue 6
10.3390/molecules27062012
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes

by
Marian Novac
1,†,
Adina Magdalena Musuc
2,*,†,
Emma Adriana Ozon
1,*,
Iulian Sarbu
3,*,
Mirela Adriana Mitu
1,*,
Adriana Rusu
2,
Daniela Gheorghe
2,
Simona Petrescu
2,
Irina Atkinson
2 and
Dumitru Lupuliasa
1
1
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania
2
“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
3
Department of Pharmaceutical Physics and Biophysics, Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Titu Maiorescu” University, 004051 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2022, 27(6), 2012; https://doi.org/10.3390/molecules27062012
Submission received: 28 February 2022 / Revised: 15 March 2022 / Accepted: 19 March 2022 / Published: 21 March 2022
(This article belongs to the Special Issue Cyclodextrin Chemistry and Toxicology II)
Browse Figures
Versions Notes

Abstract

The aim of the present study was to manufacture new orally disintegrating tablets containing nimodipine–hydroxypropyl-β-cyclodextrin and nimodipine–methyl-β-cyclodextrin inclusion complexes. For obtaining a better quality of the manufactured tablets, three methods of the preparation of inclusion complexes, in a 1:1 molar ratio, were used comparatively; namely, a solid-state kneading method and two liquid state coprecipitation and lyophilization techniques. The physical and chemical properties of the obtained inclusion complexes, as well as their physical mixtures, were investigated using Fourier transformed infrared spectroscopy, scanning electron microscopy, X-ray diffraction analyses, and differential scanning calorimetry. The results showed that the lyophilization method can be successfully used for a better complexation. Finally, the formulation and precompression studies for tablets for oral dispersion, containing Nim–HP-β-CD and Nim–Me-β-CD inclusion complexes, were successfully assessed.
Keywords: nimodipine; inclusion complexes; hydroxypropyl-β-cyclodextrin; methyl-β-cyclodextrin; orally disintegrating tablets nimodipine; inclusion complexes; hydroxypropyl-β-cyclodextrin; methyl-β-cyclodextrin; orally disintegrating tablets

Share and Cite

MDPI and ACS Style

Novac, M.; Musuc, A.M.; Ozon, E.A.; Sarbu, I.; Mitu, M.A.; Rusu, A.; Gheorghe, D.; Petrescu, S.; Atkinson, I.; Lupuliasa, D. Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes. Molecules 2022, 27, 2012. https://doi.org/10.3390/molecules27062012

AMA Style

Novac M, Musuc AM, Ozon EA, Sarbu I, Mitu MA, Rusu A, Gheorghe D, Petrescu S, Atkinson I, Lupuliasa D. Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes. Molecules. 2022; 27(6):2012. https://doi.org/10.3390/molecules27062012

Chicago/Turabian Style

Novac, Marian, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Mirela Adriana Mitu, Adriana Rusu, Daniela Gheorghe, Simona Petrescu, Irina Atkinson, and Dumitru Lupuliasa. 2022. "Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes" Molecules 27, no. 6: 2012. https://doi.org/10.3390/molecules27062012

APA Style

Novac, M., Musuc, A. M., Ozon, E. A., Sarbu, I., Mitu, M. A., Rusu, A., Gheorghe, D., Petrescu, S., Atkinson, I., & Lupuliasa, D. (2022). Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes. Molecules, 27(6), 2012. https://doi.org/10.3390/molecules27062012

Article Metrics

Back to TopTop