The Healing Capability of Clove Flower Extract (CFE) in Streptozotocin-Induced (STZ-Induced) Diabetic Rat Wounds Infected with Multidrug Resistant Bacteria
, Gamal El-Didamony 3, Basel Sitohy 4,5 and Gamal Abdel-Fattah 1
Round 1
Reviewer 1 Report
The manuscript by Ali et al utilize clove flower extracts and explored their biological potency on
wounds infected with multidrug-resistant bacteria in diabetic rats. The work is appropriate for the journal, the results are interesting, and an excellent presentation
So, I recommend that the article be accepted after minor revision
How long did the maceration last?
The explanation of Figure 3 should be expanded
Author Response
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Molecules- 1644578…….Reviewer # 1 – Round 1 |
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Does the introduction provide sufficient background and include all relevant references? |
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Ok. A background on the use of topical hydrogels based plant extracts was given. The English and word phrases of the whole manuscript were reviewed again throughout Sweden colleagues. |
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How long did the maceration last? |
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The work started Jan/ 2017 and the isolation of bacteria involved in DFU and their characterization lasted 1 year and the rest of the work completed via 2018, 2019, 2020, 2021. The manuscript was then written and submitted. |
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The explanation of Figure 3 should be expanded. |
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Thank you. It was done in the manuscript |
Reviewer 2 Report
Please see attachment.
Comments for author File: 
Comments.pdf
Author Response
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Molecules- 1644578…….Reviewer # 2 – Round 1 |
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1. It is not clear what concentration of the CFE extract was employed for in vivo experiment (topical application). Was it a hydrogel preparation? Please provide details of the exact composition |
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CFE and cefepime a hydrogel preparation was rewritten in clear and details. an corrections used were showed and given again in Materials and Methods in the manuscript. |
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2. In the introduction section, the authors are invited to mention some other phytotherapeutical approach for wound healing procedure, including examples of hydrogels. Useful information can be found at https://doi.org/10.3390/pr9112096, https://doi.org/10.3390/plants10071390 and https://doi.org/10.1016/j.biopha.2022.112730 |
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Thank you for this comment. Ok, we surveyed the links proposed and added a background on the the use of hydrogels based plant extracts for wound healing in introduction section. |
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3. Taking into account the complexity of the experimental design, a conclusion section is mandatory, highlighting the main results and future work |
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An easy and short conclusion is given in the manuscript Thank you. It was done in the manuscript |
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4. There are some minor mistakes in term of spelling/sentence correction and striketrhout to be adjusted. |
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The manuscript was reviewed nagain taking in account such note. |
