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Article

Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats

by
Priscila Faimann Sales
1,
Aline Lopes do Nascimento
1,
Fernanda Cavalcante Pinheiro
1,
Andressa Ketelem Meireles Alberto
1,
Abrahão Victor Tavares de Lima Teixeira dos Santos
1,
Helison de Oliveira Carvalho
1,
Gisele Custódio de Souza
1 and
José Carlos Tavares Carvalho
1,2,*
1
Laboratory of Drugs Research, Biology and Healthy Sciences Department, Pharmacy Faculty, Federal University of Amapá, Rod. JK, Km 02, Amapá, Macapá 68902-280, Brazil
2
University Hospital of Federal University of Amapá, Rodovia Josmar Chaves Pinto, Macapá 68903-419, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2023, 28(18), 6689; https://doi.org/10.3390/molecules28186689
Submission received: 19 July 2023 / Revised: 25 August 2023 / Accepted: 31 August 2023 / Published: 19 September 2023
(This article belongs to the Special Issue Advances in Functional Foods)
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Abstract

Dyslipidemia presents high levels of serum cholesterol and is characterized as a risk factor for cardiovascular diseases, especially for the development of atherosclerosis. E. oleracea oil (OFEO), A. esculentus oil (OFAE), B. orellana oil (OFBO), and Chronic SM® granules (CHR) are rich in bioactive compounds with the potential to treat changes in lipid metabolism. This study investigated the effects of treatments with oils from A. esculentus, E. oleracea, B. orellana, and Chronic SM® on Cocos nucifera L. saturated-fat-induced dyslipidemia. The chromatographic profile showed the majority presence of unsaturated fatty acids in the tested oils. The quantification of tocotrienols and geranylgeraniol in OFBO and CHR was obtained. Treatments with OFEO, OFAE, OFBO, and CHR were able to significantly reduce glycemia, as well as hypertriglyceridemia, total cholesterol, and LDL-cholesterol, besides increasing HDL-cholesterol. The treatments inhibited the formation of atheromatous plaques in the vascular endothelium of the treated rats. The obtained results suggest that the OFEO, OFAE, OFBO, and CHR exhibit antidyslipidemic effects and antiatherogenic activity.
Keywords: hypercholesterolemia; atherosclerosis; vegetable oils hypercholesterolemia; atherosclerosis; vegetable oils
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MDPI and ACS Style

Sales, P.F.; Nascimento, A.L.d.; Pinheiro, F.C.; Alberto, A.K.M.; Teixeira dos Santos, A.V.T.d.L.; Carvalho, H.d.O.; de Souza, G.C.; Carvalho, J.C.T. Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats. Molecules 2023, 28, 6689. https://doi.org/10.3390/molecules28186689

AMA Style

Sales PF, Nascimento ALd, Pinheiro FC, Alberto AKM, Teixeira dos Santos AVTdL, Carvalho HdO, de Souza GC, Carvalho JCT. Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats. Molecules. 2023; 28(18):6689. https://doi.org/10.3390/molecules28186689

Chicago/Turabian Style

Sales, Priscila Faimann, Aline Lopes do Nascimento, Fernanda Cavalcante Pinheiro, Andressa Ketelem Meireles Alberto, Abrahão Victor Tavares de Lima Teixeira dos Santos, Helison de Oliveira Carvalho, Gisele Custódio de Souza, and José Carlos Tavares Carvalho. 2023. "Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats" Molecules 28, no. 18: 6689. https://doi.org/10.3390/molecules28186689

APA Style

Sales, P. F., Nascimento, A. L. d., Pinheiro, F. C., Alberto, A. K. M., Teixeira dos Santos, A. V. T. d. L., Carvalho, H. d. O., de Souza, G. C., & Carvalho, J. C. T. (2023). Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar Rats. Molecules, 28(18), 6689. https://doi.org/10.3390/molecules28186689

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