Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
Abstract
:1. Introduction
2. Intramolecular Cyclization
3. Intermolecular Cyclization
4. Application in Total Synthesis of Representative Natural Products
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
DtBPF | 1,1′-Bis(di-tert-butylphosphino)ferrocene |
TES | triethylsilyl |
TMS | trimethylsilyl |
DMF | N,N-dimethylformamide |
DMA | N,N-dimethylacetamide |
DCM | dichloromethane |
THF | tetrahydrofuran |
DMSO | dimethyl sulfoxide |
TFA | trifluoroacetic acid |
dba | dibenzylideneacetone |
m-CPBA | m-chloroperbenzoic acid |
Me-phos | dicyclohexyl(2′-methyl-[1,1′-biphenyl]-2-yl)phosphane |
DPPP | 1,3-bis(diphenylphosphaneyl)propane |
TBAB | tetrabutylammonium bromide |
SN1 | unimolecular nucleophilic substitution |
Boc | tert-butoxycarbonyl |
SCN | isothiocyanato |
DDQ | 4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile |
OTBS | tert-butyldimethylsilyloxy |
PCC | pyridinium chlorochromate |
PMB | para-methoxlphenyl |
DFT | density functional theory |
o-PBA | ortho-phenyl benzoic acid |
DPPBz | 1,2-Bis(diphenylphosphino)benzene |
NBE | norbornene |
NMR | nuclear magnetic resonance |
HRMS | high resolution mass spectrometry |
Xphos | dicyclohexyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane |
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Fan, L.; Zhu, X.; Liu, X.; He, F.; Yang, G.; Xu, C.; Yang, X. Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions. Molecules 2023, 28, 1647. https://doi.org/10.3390/molecules28041647
Fan L, Zhu X, Liu X, He F, Yang G, Xu C, Yang X. Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions. Molecules. 2023; 28(4):1647. https://doi.org/10.3390/molecules28041647
Chicago/Turabian StyleFan, Liangxin, Xinxin Zhu, Xingyuan Liu, Fangyu He, Guoyu Yang, Cuilian Xu, and Xifa Yang. 2023. "Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions" Molecules 28, no. 4: 1647. https://doi.org/10.3390/molecules28041647