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Article

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

by
Qi Liu
1,
Shuai Dong
1,
Xue Zhou
2,
Yubo Zhao
1,
Bin Dong
3,
Jing Shen
3,
Kang Yang
1,
Linsen Li
1,* and
Dan Zhu
1,*
1
School of Pharmacy, Minzu University of China, Beijing 100081, China
2
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
3
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Core Laboratory, Peking University Cancer Hospital & Institute, Beijing 100142, China
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(4), 1844; https://doi.org/10.3390/molecules28041844
Submission received: 11 January 2023 / Revised: 4 February 2023 / Accepted: 13 February 2023 / Published: 15 February 2023
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Abstract

Hypertension in adolescents is associated with adverse cardiac and vascular events. In addition to lowering blood pressure, it is not clear whether pharmacological therapy in early life can improve vascular remodeling. This study aimed to evaluate the effects of long-term administration of losartan, aspirin, and atorvastatin on vascular remodeling in juvenile spontaneously hypertensive rats (SHRs). Losartan, aspirin, and atorvastatin were administered via gavage at doses of 20, 10, and 10 mg/kg/day, respectively, on SHRs aged 6–22 weeks. Paraffin sections of the blood vessels were stained with hematoxylin-eosin (H&E) and Sirius Red to evaluate the changes in the vascular structure and the accumulation of different types of collagen. The plasma levels of renin, angiotensin II (Ang II), aldosterone (ALD), endothelin-1 (ET-1), interleukin-6 (IL-6), and neutrophil elastase (NE) were determined using ELISA kits. After the 16-week treatment with losartan, aspirin, and atorvastatin, the wall thickness of the thoracic aorta and carotid artery decreased. The integrity of the elastic fibers in the tunica media was maintained in an orderly manner, and collagen deposition in the adventitia was retarded. The plasma levels of renin, ALD, ET-1, IL-6, and NE in the SHRs also decreased. These findings suggest that losartan, aspirin, and atorvastatin could improve vascular remodeling beyond their antihypertensive, anti-inflammatory, and lipid-lowering effects. Many aspects of the protection provided by pharmacological therapy are important for the prevention of cardiovascular diseases in adults and older adults.
Keywords: juvenile SHR; vascular remodeling; losartan; aspirin; atorvastatin juvenile SHR; vascular remodeling; losartan; aspirin; atorvastatin

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MDPI and ACS Style

Liu, Q.; Dong, S.; Zhou, X.; Zhao, Y.; Dong, B.; Shen, J.; Yang, K.; Li, L.; Zhu, D. Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats. Molecules 2023, 28, 1844. https://doi.org/10.3390/molecules28041844

AMA Style

Liu Q, Dong S, Zhou X, Zhao Y, Dong B, Shen J, Yang K, Li L, Zhu D. Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats. Molecules. 2023; 28(4):1844. https://doi.org/10.3390/molecules28041844

Chicago/Turabian Style

Liu, Qi, Shuai Dong, Xue Zhou, Yubo Zhao, Bin Dong, Jing Shen, Kang Yang, Linsen Li, and Dan Zhu. 2023. "Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats" Molecules 28, no. 4: 1844. https://doi.org/10.3390/molecules28041844

APA Style

Liu, Q., Dong, S., Zhou, X., Zhao, Y., Dong, B., Shen, J., Yang, K., Li, L., & Zhu, D. (2023). Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats. Molecules, 28(4), 1844. https://doi.org/10.3390/molecules28041844

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