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Volume 29
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action

by
Feiya Sheng
1,†,
Siyu Yang
1,†,
Mi Li
1,
Jiaojiao Wang
1,
Lianghong Liu
2,* and
Lele Zhang
3,*
1
College of Pharmacy, Chengdu University, Chengdu 610106, China
2
School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China
3
School of Basic Medical Sciences, Chengdu University, Chengdu 610106, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2024, 29(14), 3388; https://doi.org/10.3390/molecules29143388
Submission received: 12 June 2024 / Revised: 14 July 2024 / Accepted: 14 July 2024 / Published: 18 July 2024
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Abstract

Astragalus membranaceus saponins are the main components of A. membranaceus, a plant widely used in traditional Chinese medicine. Recently, research on the anti-cancer effects of A. membranaceus saponins has received increasing attention. Numerous in vitro and in vivo experimental data indicate that A. membranaceus saponins exhibit significant anti-cancer effects through multiple mechanisms, especially in inhibiting tumor cell proliferation, migration, invasion, and induction of apoptosis, etc. This review compiles relevant studies on the anti-cancer properties of A. membranaceus saponins from various databases over the past two decades. It introduces the mechanism of action of astragalosides, highlighting their therapeutic benefits in the management of cancer. Finally, the urgent problems in the research process are highlighted to promote A. membranaceus saponins as an effective drug against cancer.
Keywords: Astragalus membranaceus saponins; antitumor; proliferation; apoptosis; metastasis; migration; tumor microenvironment; signaling pathway Astragalus membranaceus saponins; antitumor; proliferation; apoptosis; metastasis; migration; tumor microenvironment; signaling pathway

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MDPI and ACS Style

Sheng, F.; Yang, S.; Li, M.; Wang, J.; Liu, L.; Zhang, L. Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action. Molecules 2024, 29, 3388. https://doi.org/10.3390/molecules29143388

AMA Style

Sheng F, Yang S, Li M, Wang J, Liu L, Zhang L. Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action. Molecules. 2024; 29(14):3388. https://doi.org/10.3390/molecules29143388

Chicago/Turabian Style

Sheng, Feiya, Siyu Yang, Mi Li, Jiaojiao Wang, Lianghong Liu, and Lele Zhang. 2024. "Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action" Molecules 29, no. 14: 3388. https://doi.org/10.3390/molecules29143388

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