This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers
by
Dongfeng Hong
Dongfeng Hong *,
Changzhao Wang
Changzhao Wang ,
Liujing Gao
Liujing Gao and
Caijian Nie
Caijian Nie
School of Food and Drug, Luoyang Normal University, Luoyang 471934, China
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(15), 3555; https://doi.org/10.3390/molecules29153555 (registering DOI)
Submission received: 9 June 2024
/
Revised: 22 July 2024
/
Accepted: 25 July 2024
/
Published: 28 July 2024
Abstract
Molecular imprinting has emerged as an important and practical technology to create economical and stable synthetic mimics of antibodies and enzymes. It has already found a variety of important applications, such as affinity separation, chemical/biological sensing, disease diagnostics, proteomics, bioimaging, controlled drug release, and catalysis. In the past decade, significant breakthroughs have been made in non-covalently imprinted polymers, from their synthesis through to their applications. In terms of synthesis, quite a few versatile and facile imprinting approaches for preparing MIPs have been invented, which have effectively solved some key issues in molecular imprinting. Additionally, important applications in several areas, such as sensors, proteomics and bioimaging, have been well demonstrated. In this review, we critically and comprehensively survey key recent advances made in the preparation of non-covalently imprinted polymers and their important applications. We focus on the state-of-art of this technology from three different perspectives: fundamentals, synthetic strategies, and applications. We first provide a fundamental basis for molecular imprinting technologies that have been developed, which is extremely helpful for establishing a sound understanding of the challenges in molecular imprinting. Then, we discuss in particular the major breakthroughs within the last ten years (2014–2024), with emphasis on new imprinting approaches, what strengths the breakthroughs can provide, and which new applications the properties of the prepared non-covalently imprinted polymers are fit for.
Share and Cite
MDPI and ACS Style
Hong, D.; Wang, C.; Gao, L.; Nie, C.
Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers. Molecules 2024, 29, 3555.
https://doi.org/10.3390/molecules29153555
AMA Style
Hong D, Wang C, Gao L, Nie C.
Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers. Molecules. 2024; 29(15):3555.
https://doi.org/10.3390/molecules29153555
Chicago/Turabian Style
Hong, Dongfeng, Changzhao Wang, Liujing Gao, and Caijian Nie.
2024. "Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers" Molecules 29, no. 15: 3555.
https://doi.org/10.3390/molecules29153555
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.