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Volume 29
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity

by
Elżbieta Wojaczyńska
1,
Marta Ostrowska
1,
Małgorzata Lower
1,
Natalia Czyżyk
1,
Anna Jakieła
2 and
Alberto Marra
3,*
1
Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland
2
Clinical Department of Clinical Oncology, 4th Military Clinical Hospital with Polyclinic in Wrocław, R. Weigla 5, 50-981 Wroclaw, Poland
3
Institut des Biomolécules Max Mousseron (IBMM), Université de Montpellier, 1919 Route de Mende, CEDEX 5, 34293 Montpellier, France
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(17), 4240; https://doi.org/10.3390/molecules29174240
Submission received: 27 July 2024 / Revised: 2 September 2024 / Accepted: 4 September 2024 / Published: 6 September 2024
(This article belongs to the Section Bioorganic Chemistry)
Versions Notes

Abstract

Calix[n]arenes, macrocycles constituted of 4–8 phenol moieties linked through methylene bridges, are stable molecules that can be selectively functionalised at the upper or lower rim. It has already been demonstrated that calixarene derivatives can be biologically or pharmacologically active compounds. More recently, suitably functionalised calixarenes and calixarene analogues (dihomooxacalixarenes, thiacalixarenes, calix[4]resorcinols, azacalixarenes, calixpyrroles, and pillarenes) were found to act as anticancer agents, at least in in vitro assays. We are reporting on the latest progress in this research field.
Keywords: azacalixarenes; calix[4]arenes; calix[4]resorcinols; calixpyrroles; chemotherapy; dihomooxacalixarenes; pillarenes; thiacalixarenes azacalixarenes; calix[4]arenes; calix[4]resorcinols; calixpyrroles; chemotherapy; dihomooxacalixarenes; pillarenes; thiacalixarenes

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MDPI and ACS Style

Wojaczyńska, E.; Ostrowska, M.; Lower, M.; Czyżyk, N.; Jakieła, A.; Marra, A. Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity. Molecules 2024, 29, 4240. https://doi.org/10.3390/molecules29174240

AMA Style

Wojaczyńska E, Ostrowska M, Lower M, Czyżyk N, Jakieła A, Marra A. Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity. Molecules. 2024; 29(17):4240. https://doi.org/10.3390/molecules29174240

Chicago/Turabian Style

Wojaczyńska, Elżbieta, Marta Ostrowska, Małgorzata Lower, Natalia Czyżyk, Anna Jakieła, and Alberto Marra. 2024. "Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity" Molecules 29, no. 17: 4240. https://doi.org/10.3390/molecules29174240

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