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Article

Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex

by
Yi Song
†,
Shiyu Wang
† and
Yan Xu
*
Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2024, 29(20), 4900; https://doi.org/10.3390/molecules29204900
Submission received: 19 September 2024 / Revised: 11 October 2024 / Accepted: 14 October 2024 / Published: 16 October 2024
(This article belongs to the Section Chemical Biology)
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Abstract

Until now, Z-form RNAs were believed to only adopt a left-handed double-helix structure. In this study, we describe the first observation of a right-handed Z-form RNA in NMR solution formed by L-nucleic acid RNA and present the first resolution of structure of the complex between a right-handed Z-form RNA and a curaxin ligand. These results provide a platform for the design of topology specific to Z-form-targeting compounds and are valuable for the development of new potent anticancer drugs.
Keywords: mirror image; right hand; Z-form L-RNA; RNA-ligand complex mirror image; right hand; Z-form L-RNA; RNA-ligand complex
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MDPI and ACS Style

Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Molecules 2024, 29, 4900. https://doi.org/10.3390/molecules29204900

AMA Style

Song Y, Wang S, Xu Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Molecules. 2024; 29(20):4900. https://doi.org/10.3390/molecules29204900

Chicago/Turabian Style

Song, Yi, Shiyu Wang, and Yan Xu. 2024. "Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex" Molecules 29, no. 20: 4900. https://doi.org/10.3390/molecules29204900

APA Style

Song, Y., Wang, S., & Xu, Y. (2024). Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Molecules, 29(20), 4900. https://doi.org/10.3390/molecules29204900

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