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Article

Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function

College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Molecules 2024, 29(3), 732; https://doi.org/10.3390/molecules29030732
Submission received: 26 December 2023 / Revised: 26 January 2024 / Accepted: 3 February 2024 / Published: 5 February 2024
(This article belongs to the Special Issue Research on Natural Products for Intestinal Disorders)

Abstract

The global increase in antibiotic consumption is related to increased adverse effects, such as antibiotic-associated diarrhea (AAD). This study investigated the chemical properties of Zingiber officinale Rosc (ZO) extract and its ameliorative effects using a lincomycin-induced AAD mouse model. Intestinal tissues were evaluated for the expression of lysozyme, claudin-1, and α-defensin-1, which are associated with intestinal homeostasis. The cecum was analyzed to assess the concentration of short-chain fatty acids (SCFAs). The chemical properties analysis of ZO extracts revealed the levels of total neutral sugars, acidic sugars, proteins, and polyphenols to be 86.4%, 8.8%, 4.0%, and 0.8%, respectively. Furthermore, the monosaccharide composition of ZO was determined to include glucose (97.3%) and galactose (2.7%). ZO extract administration ameliorated the impact of AAD and associated weight loss, and water intake also returned to normal. Moreover, treatment with ZO extract restored the expression levels of lysozyme, α-defensin-1, and claudin-1 to normal levels. The decreased SCFA levels due to induced AAD showed a return to normal levels. The results indicate that ZO extract improved AAD, strengthened the intestinal barrier, and normalized SCFA levels, showing that ZO extract possesses intestinal-function strengthening effects.
Keywords: antibiotic-associated diarrhea; intestinal barrier; short-chain fatty acid; Zingiber officinale Roscoe antibiotic-associated diarrhea; intestinal barrier; short-chain fatty acid; Zingiber officinale Roscoe

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MDPI and ACS Style

Kim, S.J.; Shin, M.-S.; Choi, Y.-K. Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function. Molecules 2024, 29, 732. https://doi.org/10.3390/molecules29030732

AMA Style

Kim SJ, Shin M-S, Choi Y-K. Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function. Molecules. 2024; 29(3):732. https://doi.org/10.3390/molecules29030732

Chicago/Turabian Style

Kim, Sung Jin, Myoung-Sook Shin, and You-Kyung Choi. 2024. "Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function" Molecules 29, no. 3: 732. https://doi.org/10.3390/molecules29030732

APA Style

Kim, S. J., Shin, M.-S., & Choi, Y.-K. (2024). Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function. Molecules, 29(3), 732. https://doi.org/10.3390/molecules29030732

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