Molecules

12 pages, 68 KB

Open AccessArticle

Evaluation of Effect of Microwave Irradiation on Syntheses and Reactions of Some New 3-Acyl-methylchromones

by Margita Lacova, Hafez M. El-Shaaer, Dusan Loos, Maria Matulova, Jarmila Chovancova and Mikulas Furdik

Molecules 1998, 3(3), 120-131; https://doi.org/10.3390/30300120 - 10 Mar 1998

Cited by 17 | Viewed by 7987

Abstract

The 3-Acyl-2-R-methylchromones (R = H, ArO, C₆H₄(CO)₂N) were prepared in good yields by different methods from 2-hydroxyaroylacetone derivatives. Some subsequent reactions of these compounds with hydroxylamine and 3-formylchromones are described. The effect of microwave irradation on some condensation reactions was studied. Full article

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Scheme 1

13 pages, 466 KB

Open AccessArticle

Enantiodivergent Synthesis of (R)- and (S)-Rolipram

by Joachim Demnitz, Luigi LaVecchia, Edmond Bacher, Thomas H. Keller, Thomas Müller, Friedrich Schürch, Hans-Peter Weber and Esteban Pombo-Villar

Molecules 1998, 3(3), 107-119; https://doi.org/10.3390/30300107 - 10 Mar 1998

Cited by 38 | Viewed by 11478

Abstract

Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation [...] Read more.

Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation gave (R)-(-)-1 and (S)-(+)-1, respectively. CD spectra of both enantiomers of rolipram are reported and discussed. Both enantiomers of rolipram presented the same potency of inhibitory activity against recombinant cyclic-AMP-selective phosphodiesterase (PDE4) subtypes. Full article

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7 pages, 41 KB

Open AccessArticle

A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones

by Anatoly D. Shutalev, Ekaterina A. Kishko, Natalie V. Sivova and Aleksei Yu. Kuznetsov

Molecules 1998, 3(3), 100-106; https://doi.org/10.3390/30300100 - 9 Mar 1998

Cited by 121 | Viewed by 9061

Abstract

An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. Full article

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Scheme 1

6 pages, 414 KB

Open AccessReview

Elemental and Molecular Heritage: An Internet-based Display

by Henry S. Rzepa

Molecules 1998, 3(3), 94-99; https://doi.org/10.3390/30300094 - 9 Mar 1998

Cited by 6 | Viewed by 9305

Abstract

The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are [...] Read more.

The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are shown, together with a recently discovered heterocyclic systems scorpionine, which like mauveine is made by a deceptively simple chemical synthesis. Full article

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2 pages, 106 KB

Open AccessShort Note

(E)-3-(2-Methoxyphenyl)-2-butenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M73; https://doi.org/10.3390/M73 - 6 Mar 1998

Viewed by 4403

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 116 KB

Open AccessShort Note

Ethyl (Z)-3-(2-Methoxyphenyl)-2-butenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M72; https://doi.org/10.3390/M72 - 6 Mar 1998

Cited by 1 | Viewed by 4440

Abstract

The synthetic procedure [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 119 KB

Open AccessShort Note

Ethyl (E)-3-(2-Methoxyphenyl)-2-butenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M71; https://doi.org/10.3390/M71 - 6 Mar 1998

Viewed by 4435

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 103 KB

Open AccessShort Note

bis-[(Z)-5-Phenyl-2-penten-2-yl]mercury

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M70; https://doi.org/10.3390/M70 - 6 Mar 1998

Cited by 1 | Viewed by 4301

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 101 KB

Open AccessShort Note

[(Z)-5-Phenyl-2-penten-2-yl]mercury Acetate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M69; https://doi.org/10.3390/M69 - 6 Mar 1998

Cited by 1 | Viewed by 4320

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 99 KB

Open AccessShort Note

[(Z)-5-Phenyl-2-penten-2-yl]mercury Bromide

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M68; https://doi.org/10.3390/M68 - 6 Mar 1998

Cited by 1 | Viewed by 4228

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 102 KB

Open AccessShort Note

Tributyl-[(Z)-5-phenyl-2-penten-2-yl]stannane

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M67; https://doi.org/10.3390/M67 - 6 Mar 1998

Cited by 4 | Viewed by 4631

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 103 KB

Open AccessShort Note

(Z)-2-Bromo-5-phenyl-2-pentene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M66; https://doi.org/10.3390/M66 - 6 Mar 1998

Viewed by 4860

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 96 KB

Open AccessShort Note

2,3-Dibromo-2-methyl-5-phenylpentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M65; https://doi.org/10.3390/M65 - 6 Mar 1998

Viewed by 4423

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 104 KB

Open AccessShort Note

(E)-2-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M64; https://doi.org/10.3390/M64 - 6 Mar 1998

Viewed by 4362

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 112 KB

Open AccessShort Note

Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M63; https://doi.org/10.3390/M63 - 6 Mar 1998

Viewed by 4209

Abstract

The synthetic procedure [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 116 KB

Open AccessShort Note

Ethyl (E)-2-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M62; https://doi.org/10.3390/M62 - 6 Mar 1998

Viewed by 4445

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 97 KB

Open AccessShort Note

3-Hydroxy-3-methyl-5-phenylpentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M61; https://doi.org/10.3390/M61 - 6 Mar 1998

Viewed by 4322

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 98 KB

Open AccessShort Note

Ethyl 3-Acetoxy-3-methyl-5-phenylpentanoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M60; https://doi.org/10.3390/M60 - 6 Mar 1998

Viewed by 4155

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 97 KB

Open AccessShort Note

Ethyl 3-Hydroxy-3-methyl-5-phenylpentanoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M59; https://doi.org/10.3390/M59 - 6 Mar 1998

Cited by 1 | Viewed by 4203

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 104 KB

Open AccessShort Note

(E)-1-Bromo-2-methyl-4-phenyl-1-butene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M58; https://doi.org/10.3390/M58 - 6 Mar 1998

Viewed by 4604

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 102 KB

Open AccessShort Note

(Z)-1-Bromo-2-methyl-4-phenyl-1-butene

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M57; https://doi.org/10.3390/M57 - 6 Mar 1998

Viewed by 4330

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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Figure 1

1 pages, 103 KB

Open AccessShort Note

2(R,S),3(S,R)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M56; https://doi.org/10.3390/M56 - 6 Mar 1998

Cited by 1 | Viewed by 4427

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 103 KB

Open AccessShort Note

2(S,R),3(R,S)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M55; https://doi.org/10.3390/M55 - 6 Mar 1998

Cited by 2 | Viewed by 4712

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

1 pages, 102 KB

Open AccessShort Note

(Z)-3-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M54; https://doi.org/10.3390/M54 - 6 Mar 1998

Viewed by 4567

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 105 KB

Open AccessShort Note

(E)-3-Methyl-5-phenyl-2-pentenoic Acid

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M53; https://doi.org/10.3390/M53 - 6 Mar 1998

Viewed by 4352

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 115 KB

Open AccessShort Note

Ethyl (Z)-3-Methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M52; https://doi.org/10.3390/M52 - 6 Mar 1998

Viewed by 4255

Abstract

The synthetic procedure [1] has been presented elsewhere. Ethyl (Z)-3-methyl-5-phenyl-2-pentenoate was obtained (2.23 g, 23%) as a colourless oil.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 119 KB

Open AccessShort Note

Ethyl (E)-3-methyl-5-phenyl-2-pentenoate

by Martin J. Stoermer and John T. Pinhey

Molecules 1998, 3(3), M51; https://doi.org/10.3390/M51 - 6 Mar 1998

Cited by 1 | Viewed by 4424

Abstract

The general part of the experimental section [1] has been presented elsewhere.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

6 pages, 55 KB

Open AccessArticle

Application of Microwave in Organic Synthesis. Dry Synthesis of 2-Arylmethylene-3(2)-naphthofuranones

by Didier Villemin, Benoit Martin and Nathalie Bar

Molecules 1998, 3(3), 88-93; https://doi.org/10.3390/30300088 - 5 Mar 1998

Cited by 25 | Viewed by 9100

Abstract

3(2)-Naphthofuranone (1) was condensed in the presence of Al₂O₃-KF with aromatic aldehydes (4) to give arylidenenaphthofuranones (5a-f) without solvent under focused microwave irradiation. Full article

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2 pages, 91 KB

Open AccessShort Note

Methyl 2,3-O-Isopropylidene-a-D-mannofuranoside 5,6-Carbonate

by Bohumil Steiner, Jan Gajdos and Miroslav Koos

Molecules 1998, 3(3), M50; https://doi.org/10.3390/M50 - 4 Mar 1998

Viewed by 3427

Abstract

Sugar carbonates can be prepared by the condensation of the cis-glycol system of the carbohydrate with phosgene or with a chloroformic ester [1,2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

2 pages, 117 KB

Open AccessShort Note

Cycloartan-2b-2-methyl ButanoateIsolated from Genus Espeletia (Asteraceae)

by Tellez Nohemi, Torrenegra Ruben, Pedroyo Julio and Gray Alexander

Molecules 1998, 3(3), M49; https://doi.org/10.3390/M49 - 4 Mar 1998

Cited by 2 | Viewed by 3523

Abstract

We describe the isolation and characterization of a new cycloartane-type triterpenes, cycloartan- 2b-2-methyl butanoate.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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Molecules, Volume 3, Issue 3 (March 1998) – 35 articles , Pages 51-131, Articles M49-M73

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