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Review

Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate

1
School of Food and Bioengineering, Wuhu Institute of Technology, Wuhu 241003, China
2
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(6), 1241; https://doi.org/10.3390/molecules30061241
Submission received: 21 January 2025 / Revised: 4 March 2025 / Accepted: 6 March 2025 / Published: 10 March 2025

Abstract

Vitamin E succinate is a more mature vitamin E derivative, and its chemical stability and many effects have been improved compared with vitamin E, which can not only make up for the shortcomings of vitamin E application but also broaden the application field of vitamin E. At present, in developed countries such as Europe, America, and Japan, vitamin E succinate is widely used in health foods, and due to its good water solubility and stability, the vitamin E added to most nutritional supplements (tablets and hard capsules) is vitamin E succinate. At the same time, vitamin E succinate used in the food and pharmaceutical industries is mainly catalyzed by enzymatic catalysis. In this paper, Candida rugosa lipase (CRL) was studied. Chemical modification and immobilization were used to improve the enzymatic properties of CRL, and immobilized lipase with high stability and high activity was obtained. It was applied to the enzymatic synthesis of vitamin E succinate, and the reaction conditions were optimized to improve the yield and reduce the production cost. The review covered the research progress of the methods for enhancing the catalytic performance of immobilized enzymes and discussed its application in the synthesis of vitamin E succinate, providing new ideas and technical support for the catalytic performance enhancement of immobilized enzymes and its application in the synthesis of vitamin E succinate and promoting the production and application of vitamin E succinate.
Keywords: immobilized lipase; nanomaterials; vitamin E succinate; enzymatic catalysis immobilized lipase; nanomaterials; vitamin E succinate; enzymatic catalysis

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MDPI and ACS Style

Qu, L.; Lu, Q.; Zhang, L.; Kong, F.; Zhang, Y.; Lin, Z.; Ni, X.; Zhang, X.; Zhao, Y.; Zou, B. Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate. Molecules 2025, 30, 1241. https://doi.org/10.3390/molecules30061241

AMA Style

Qu L, Lu Q, Zhang L, Kong F, Zhang Y, Lin Z, Ni X, Zhang X, Zhao Y, Zou B. Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate. Molecules. 2025; 30(6):1241. https://doi.org/10.3390/molecules30061241

Chicago/Turabian Style

Qu, Liang, Qiongya Lu, Liming Zhang, Fanzhuo Kong, Yuyang Zhang, Zhiyuan Lin, Xing Ni, Xue Zhang, Yani Zhao, and Bin Zou. 2025. "Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate" Molecules 30, no. 6: 1241. https://doi.org/10.3390/molecules30061241

APA Style

Qu, L., Lu, Q., Zhang, L., Kong, F., Zhang, Y., Lin, Z., Ni, X., Zhang, X., Zhao, Y., & Zou, B. (2025). Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate. Molecules, 30(6), 1241. https://doi.org/10.3390/molecules30061241

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