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Volume 30
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Review

Current Progress of Hederagenin and Its Derivatives for Disease Therapy (2017–Present)

by
Wang Wang
1,
Yan Jin
1,
Meng-Ke Liu
1,
Sai-Yang Zhang
2,3,
Hong Chen
1,* and
Jian Song
2,3,*
1
Luoyang Key Laboratory of Organic Functional Molecules, School of Food and Drug, Luoyang Normal University, Luoyang 471934, China
2
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
3
State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou 450001, China
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(6), 1275; https://doi.org/10.3390/molecules30061275
Submission received: 21 January 2025 / Revised: 24 February 2025 / Accepted: 3 March 2025 / Published: 12 March 2025
(This article belongs to the Special Issue Small-Molecule Inhibitors: Synthesis, Cytotoxicity and Biological Activities)
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Abstract

Natural products have emerged as crucial sources of biologically active compounds, holding promise for applications in drug development. Among the extensively researched pentacyclic triterpenes, hederagenin (HG) stands out for its diverse biological activities and serves as a valuable scaffold for synthesizing novel derivatives. These derivatives hold significant promise for the development of novel therapeutic agents aimed at treating a wide range of diseases. Over the past years, a multitude of HG derivatives with varied bioactivities have been synthesized through chemical modifications. This review article consolidates the most recent findings (since 2017) on HG derivatives, emphasizing their biological effects and mechanisms of action in both in vitro and in vivo models. The objective of this compilation is to offer insights and direct future research endeavors in the realm of HG.
Keywords: hederagenin; structural modification; bioactivity; drug discovery hederagenin; structural modification; bioactivity; drug discovery

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MDPI and ACS Style

Wang, W.; Jin, Y.; Liu, M.-K.; Zhang, S.-Y.; Chen, H.; Song, J. Current Progress of Hederagenin and Its Derivatives for Disease Therapy (2017–Present). Molecules 2025, 30, 1275. https://doi.org/10.3390/molecules30061275

AMA Style

Wang W, Jin Y, Liu M-K, Zhang S-Y, Chen H, Song J. Current Progress of Hederagenin and Its Derivatives for Disease Therapy (2017–Present). Molecules. 2025; 30(6):1275. https://doi.org/10.3390/molecules30061275

Chicago/Turabian Style

Wang, Wang, Yan Jin, Meng-Ke Liu, Sai-Yang Zhang, Hong Chen, and Jian Song. 2025. "Current Progress of Hederagenin and Its Derivatives for Disease Therapy (2017–Present)" Molecules 30, no. 6: 1275. https://doi.org/10.3390/molecules30061275

APA Style

Wang, W., Jin, Y., Liu, M.-K., Zhang, S.-Y., Chen, H., & Song, J. (2025). Current Progress of Hederagenin and Its Derivatives for Disease Therapy (2017–Present). Molecules, 30(6), 1275. https://doi.org/10.3390/molecules30061275

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