Influence of Some Thia- or Azasubstituted Butyric Acid Derivatives on the Chemical Shift of the Benzene Ring Carbon Atoms
Abstract
:Introduction
Results and Discussion
Experimental
General
4-Phenyl-3-aza-2,2-tetramethylene butyric acid derivatives 1e and 1g
References and Notes
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- ACD / CNMR: Advanced Chemistry Development Inc., 141 Adelaide Street West Suite 1501, Toronto, Ontario, M5H 3L5, Canada.
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- Samples Availability: Not available.
No. | X | Y | R1 | R2 | R | No. | X | Y | R1 | R2 | R |
---|---|---|---|---|---|---|---|---|---|---|---|
1a | CH2 | S | H | H | COOH | 1e | CH2 | NH | - ( CH2 )4 - | CN | |
1b | S | CH2 | H | H | COOH | 1f | CH2 | NH | - ( CH2 )4 - | COOH | |
1c | CH2 | S | H | H | COOMe | 1g | CH2 | NMe | - ( CH2 )4 - | CN | |
1d | S | CH2 | H | H | COOMe | 1h | CH2 | NMe | - ( CH2 )4 - | COOH |
- X - Y - CR1R2R* | Cipso | Corto | Cmeta | Cpara | Other signals | |
---|---|---|---|---|---|---|
- CH2-S-CH2-COOH, 1a | δ | 136.8 | 129.2 | 128.6 | 127.4 | 176.8, 36.3, 31.9 |
Δ δ | +8.3 | +0.7 | +0.1 | -1.1 | ||
-S-CH2CH2-COOH, 1b | δ | 135.0 | 130.1 | 129.0 | 126.6 | 177.1, 34.4, 30.9 |
Δ δ | +6.5 | +1.6 | +0.5 | -1.9 | ||
-CH2-S-CH2-COOMe, 1c | δ | 137.0 | 128.9 | 128.3 | 127.0 | 170.5, 52.0, 36.1, 31.8 |
Δ δ | +8.5 | +0.4 | -0.2 | -1.5 | ||
-S-CH2CH2-COOMe, 1d | δ | 135.0 | 129.8 | 128.8 | 126.3 | 171.8, 51.5, 33.9, 28.7 |
Δ δ | +6.5 | +1.3 | +0.3 | -2.2 | ||
-CH2-NH-C(CH2)4CN, 1e | δ | 139.2 | 128.5 | 128.3 | 127.3 | 122.9, 61.2, 50.2, 39.0, 23.5 |
Δ δ | +10.7 | 0 | -0.2 | -1.2 | ||
-CH2-NH-C(CH2)4COOH, 1f | δ | 140.0 | 128.4 | 127.7 | 127.0 | 179.5, 70.0, 48.4, 35.8, 24.2 |
Δ δ | +11.5 | -0.1 | -0.8 | -1.5 | ||
-CH2-NMe-C(CH2)4CN, 1g | δ | 138.3 | 128.5 | 128.2 | 126.8 | 120.2, 68.8, 58.4, 38.5, 37.9, 23.2 |
Δ δ | +9.8 | 0 | -0.3 | -1.7 | ||
-CH2-NMe-C(CH2)4COOH, 1ha | δ | 140.0 | 128.3 | 128.2 | 126.7 | 176.6, 74.7, 56.7, 36.0, 32.1, 24.8 |
Δ δ | +11.5 | -0.2 | -0.3 | -1.8 |
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Fröhlich, J.; Sauter, F.; Milata, V. Influence of Some Thia- or Azasubstituted Butyric Acid Derivatives on the Chemical Shift of the Benzene Ring Carbon Atoms. Molecules 2000, 5, 616-619. https://doi.org/10.3390/50300616
Fröhlich J, Sauter F, Milata V. Influence of Some Thia- or Azasubstituted Butyric Acid Derivatives on the Chemical Shift of the Benzene Ring Carbon Atoms. Molecules. 2000; 5(3):616-619. https://doi.org/10.3390/50300616
Chicago/Turabian StyleFröhlich, Johannes, Fritz Sauter, and Viktor Milata. 2000. "Influence of Some Thia- or Azasubstituted Butyric Acid Derivatives on the Chemical Shift of the Benzene Ring Carbon Atoms" Molecules 5, no. 3: 616-619. https://doi.org/10.3390/50300616