Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects
Abstract
:1. Introduction
2. Controlled Drug Release Technology of Drugs
3. Types and Classes of Biodegradable and Biocompatible Pharmaceutical Polymers
3.1. Polyester-Based Synthetic Polymers
3.2. Natural Origin Polymers Used as Pharmaceutical Excipients
3.3. Homo vs. Diblock Copolymer vs. Triblock Copolymers
4. Therapeutic Agents Encapsulated in Polymeric Particles
5. Types of Polymeric Pharmaceutical/Drug Delivery Particles
5.1. Microparticles for Controlled Release Delivery
5.2. Nanoparticles for Controlled Release Delivery
6. Manufacturing/Particle Engineering Design of Polymeric Microparticles and Nanoparticles
6.1. Double-Emulsion Evaporation Methods
6.2. Supercritical Fluid (SCF) Technology
6.3. Supercritical Antisolvent Method
6.4. Spray Drying Particle Engineering Design
7. Marketed Controlled Release Polymeric Pharmaceutical Products and Clinical Trials
8. Conclusions
References
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Polymeric inactive ingredients for FDA-approved drug products | |
---|---|
Polyester-based synthetic polymers | PLGA (for IM, SC uses) Poloxamer (for oral, topical, IV opthalmic, SC uses) Polyvinylpyrrolidone ethylcellulose (for oral use) Sodium pyrrolidone carboxylate (for topical use) Povidone (for oral, intra-articular, IM, Intrauterine, topical, SC, respiratory, opthalmic uses) PLA (for IM use) PEG (for oral, respiratory, topical, IM, IV, opthalmic uses) PVA (for auricular, IM, intraocular, topical uses) KOLLIDON VA 64 (for oral use) |
Natural-origin polymers | Starch (for oral, IV, IM, topical) Hyaluronate (for intra-articular, IM, intravitreal, topical uses), Human albumin (for IV, SC, Oral uses) Gelatin (for IM, SC, IV, oral topical uses) Alginic acid (for opthalmic and oral uses) Collagen (for topical use) |
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Mansour, H.M.; Sohn, M.; Al-Ghananeem, A.; DeLuca, P.P. Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects. Int. J. Mol. Sci. 2010, 11, 3298-3322. https://doi.org/10.3390/ijms11093298
Mansour HM, Sohn M, Al-Ghananeem A, DeLuca PP. Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects. International Journal of Molecular Sciences. 2010; 11(9):3298-3322. https://doi.org/10.3390/ijms11093298
Chicago/Turabian StyleMansour, Heidi M., MinJi Sohn, Abeer Al-Ghananeem, and Patrick P. DeLuca. 2010. "Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects" International Journal of Molecular Sciences 11, no. 9: 3298-3322. https://doi.org/10.3390/ijms11093298